amfAR, The Foundation for AIDS Research

 

Publications from amfAR Grantees and Fellows (2014 - 2013)

Click here for publications prior to 2013.

Publications of amfAR Grantees and Fellows

Introduction

Each month, the findings of amfAR-funded researchers (names in bold) are published in peer-reviewed journals, which are listed below by month of publication. In each case you can click on the “ABSTRACT” link for a brief summary of the research paper as it appears in the journal. In some cases, you can click on the "READ MORE" link to access related articles written for a lay audience by amfAR staff. 

 

September 2014

Lipopolysaccharide, immune activation, and liver abnormalities in HIV/hepatitis B virus (HBV)-coinfected individuals receiving HBV-active combination antiretroviral therapy.
Crane M, Avihingsanon A, Rajasuriar R, Velayudham P, Iser D, Solomon A, Sebolao B, Tran A, Spelman T, Matthews G, Cameron P, Tangkijvanich P, Dore GJ, Ruxrungtham K, Lewin SR.
J Infect Dis. 2014 Sep 1;210(5):745-51.

 

Long-term antiretroviral treatment initiated at primary HIV-1 infection affects the size, composition, and decay kinetics of the reservoir of HIV-1-infected CD4 T cells.
Buzon MJ, Martin-Gayo E, Pereyra F, Ouyang Z, Sun H, Li JZ, Piovoso M, Shaw A, Dalmau J, Zangger N, Martinez-Picado J, Zurakowski R, Yu XG, Telenti A, Walker BD, Rosenberg ES, Lichterfeld M.
J Virol. 2014 Sep 1;88(17):10056-65.
READ MORE: Viral Reservoirs: How Low Must We Go?   

 

Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1.
Hill AL, Rosenbloom DI, Fu F, Nowak MA, Siliciano RF.
Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13475-80.
READ MORE: Viral Reservoirs: How Low Must We Go? 

 

The Histone Deacetylase Inhibitor Vorinostat (SAHA) Increases the Susceptibility of Uninfected CD4+ T Cells to HIV by Increasing the Kinetics and Efficiency of Postentry Viral Events.
Lucera MB, Tilton CA, Mao H, Dobrowolski C, Tabler CO, Haqqani AA, Karn J, Tilton JC.
J Virol. 2014 Sep 15;88(18):10803-12.

 

August 2014

Levels of circulating myeloid subpopulations and of heme oxygenase-1 do not predict CD4(+) T cell recovery after the initiation of antiretroviral therapy for HIV disease.
Seu L, Ortiz GM, Burt TD, Deeks SG, Martin JN, McCune JM.
AIDS Res Ther. 2014 Aug 5;11:27.

 

Cutting Edge: An Antibody Recognizing Ancestral Endogenous Virus Glycoproteins Mediates Antibody-Dependent Cellular Cytotoxicity on HIV-1-Infected Cells.
Michaud HA, SenGupta D, de Mulder M, Deeks SG, Martin JN, Kobie JJ, Sacha JB, Nixon DF.
J Immunol. 2014 Aug 15;193(4):1544-8.
READ MORE: Innovative New Approaches to Designing HIV Vaccines

 

Differential glycosylation of envelope gp120 is associated with differential recognition of HIV-1 by virus-specific antibodies and cell infection.
Raska M, Czernekova L, Moldoveanu Z, Zachova K, Elliott MC, Novak Z, Hall S, Hoelscher M, Maboko L, Brown R, Smith PD, Mestecky J, Novak J.
AIDS Res Ther. 2014 Aug 1;11:23.
READ MORE: Innovative New Approaches to Designing HIV Vaccines

 

The use of BLT mice to investigate the immune reconstitutionin the gastrointestinal tract.
Wahl A, Garcia JV. J Immunol Methods. 410:28-33.
  

July 2014

Immunologic strategies for HIV-1 remission and eradication.
Barouch DH, Deeks SG.
Science. 2014 Jul 11;345(6193):169-74.
 

Programmed death-1 expression on CD4+ and CD8+ T cells in treated and untreated HIV disease.
Cockerham LR, Jain V, Sinclair E, Glidden DV, Hartogenesis W, Hatano H, Hunt PW, Martin JN, Pilcher CD, Sekaly R, McCune JM, Hecht FM, Deeks SG.
AIDS. 2014 Jul 31;28(12):1749-58.
  

HIV-1 capture and transmission by dendritic cells: the role of viral glycolipids and the cellular receptor Siglec-1.
Izquierdo-Useros N, Lorizate M, McLaren PJ, Telenti A, Kräusslich HG, Martinez-Picado J.
PLoS Pathog. 2014 Jul 17;10(7):e1004146
  

Vaginal Myeloid Dendritic Cells Transmit Founder HIV-1.
Shen R, Kappes JC, Smythies LE, Richter HE, Novak L, Smith PD.
J Virol. 2014 Jul 1;88(13):7683-8.
READ MORE: Unraveling the Mechanisms of Male-to-Female HIV Transmission

 


 

June 2014

Prevention of HIV-1 transmission with postexposure prophylaxis after inadvertent infected blood transfusion.
Al-Hajjar SH, Frayha HH, Al-Hazmi M, Batawi R, McIntosh K, Sax PE, Al-Thawadi S, Al-Jumaah S, Busch MP, Hanhauser E, Kuritzkes DR, Li JZ, Henrich TJ.
AIDS. 2014 Jun 19;28(10):1539-41.

A Cell-Intrinsic Inhibitor of HIV-1 Reverse Transcription in CD4(+) T Cells from Elite Controllers.
Leng J, Ho HP, Buzon MJ, Pereyra F, Walker BD, Yu XG, Chang EJ, Lichterfeld M.
Cell Host Microbe. 2014 Jun 11;15(6):717-28.
READ MORE:   How Cells Resist HIV Infection: New Clues

CD4-Mimetic Small Molecules Sensitize Human Immunodeficiency Virus to Vaccine-Elicited Antibodies.
Madani N, Princiotto AM, Schön A, LaLonde J, Feng Y, Freire E, Park J, Courter JR, Jones DM, Robinson J, Liao HX, Moody MA, Permar S, Haynes B, Smith AB 3rd, Wyatt R, Sodroski J.
J Virol. 2014 Jun 15;88(12):6542-6555.

Unraveling the relationship between microbial translocation and systemic immune activation in HIV infection.
Shan L, Siliciano RF.
J Clin Invest. 2014 Jun 2;124(6):2368-71.

Quantification of Integrated HIV DNA by Repetitive-Sampling Alu-HIV PCR on the Basis of Poisson Statistics.
De Spiegelaere W, Malatinkova E, Lynch L, Van Nieuwerburgh F, Messiaen P, O'Doherty U, Vandekerckhove L.
Clin Chem. 2014 Jun;60(6):886-95.

 


 

May 2014

An Example of Genetically Distinct HIV Type 1 Variants in Cerebrospinal Fluid and Plasma During Suppressive Therapy.
Dahl V, Gisslen M, Hagberg L, Peterson J, Shao W, Spudich S, Price RW, Palmer S.
J Infect Dis. 2014 May;209(10):1618-22.

HIV Antibody Characterization as a Method to Quantify Reservoir Size During Curative Interventions.
Burbelo PD, Bayat A, Rhodes CS, Hoh R, Martin JN, Fromentin R, Chomont N, Hütter G, Kovacs JA, Deeks SG.
J Infect Dis. 2014 May;209(10):1613-7.

HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality.
Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG.
PLoS Pathog. 2014 May 15;10(5):e1004078

Loss of a conserved N-linked glycosylation site in the simian immunodeficiency virus envelope glycoprotein V2 region enhances macrophage tropism by increasing CD4-independent cell-to-cell transmission.
Yen PJ, Herschhorn A, Haim H, Salas I, Gu C, Sodroski J, Gabuzda D.
J Virol. 2014 May;88(9):5014-28.

Hepatitis C therapy with interferon-α and ribavirin reduces CD4 T-cell-associated HIV-1 DNA in HIV-1/hepatitis C virus-coinfected patients.
Sun H1, Buzon MJ, Shaw A, Berg RK, Yu XG, Ferrando-Martinez S, Leal M, Ruiz-Mateos E, Lichterfeld M.
J Infect Dis. 2014 May 1;209(9):1315-20.
READ MORE: Possible New Use for an Old Antiviral Drug in Attacking Latent HIV

BCA2/Rabring7 Targets HIV-1 Gag for Lysosomal Degradation in a Tetherin-Independent Manner.
Nityanandam R, Serra-Moreno R.
PLoS Pathog. 2014 May 22;10(5):e1004151

CD4+ memory stem cells are infected by HIV-1 in a manner regulated in part by SAMHD1 expression.
Tabler CO, Lucera MB, Haqqani AA, McDonald DJ, Migueles SA, Connors M, Tilton JC.
J Virol. 2014 May;88(9):4976-86.
 

 


 

April 2014

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.
Bullen CK, Laird GM, Durand CM, Siliciano JD, Siliciano RF.
Nat Med. 2014 Apr;20(4):425-9.
READ MORE: Additional Approaches to Attacking the HIV Reservoir 
 

Reduced markers of HIV persistence and restricted HIV-specific immune responses after early antiretroviral therapy in children.
Ananworanich J, Puthanakit T, Suntarattiwong P, Chokephaibulkit K, Kerr SJ, Fromentin R, Bakeman W, Intasan J, Mahanontharit A, Sirivichayakul S, Chomont N.
AIDS. 2014 Apr 24;28(7):1015-20.
 

Transcriptional control of HIV latency: Cellular signaling pathways, epigenetics, happenstance and the hope for a cure.
Mbonye U, Karn J.
Virology. 2014 Apr;454-455C:328-339.
READ MORE: Additional Approaches to Attacking the HIV Reservoir
 

Positive selection of primate genes that promote HIV-1 replication.
Meyerson NR, Rowley PA, Swan CH, Le DT, Wilkerson GK, Sawyer SL.
Virology. 2014 Apr;454-455:291-8.
 

A novel cell-based high-throughput screen for inhibitors of HIV-1 gene expression and budding identifies the cardiac glycosides.
Laird GM, Eisele EE, Rabi SA, Nikolaeva D, Siliciano RF.
J Antimicrob Chemother. 2014 Apr;69(4):988-94.
READ MORE: Additional Approaches to Attacking the HIV Reservoir 
 

Hepatitis C therapy with interferon-α and ribavirin reduces CD4 T-cell-associated HIV-1 DNA in HIV-1/hepatitis C virus-coinfected patients.
Sun H, Buzon MJ, Shaw A, Berg RK, Yu XG, Ferrando-Martinez S, Leal M, Ruiz-Mateos E, Lichterfeld M.
J Infect Dis. 2014 May 1;209(9):1315-20. doi: 10.1093/infdis/jit628. Epub 2013 Nov 25.

 


 

March 2014

A Pilot Study Assessing the Safety and Latency-Reversing Activity of Disulfiram in HIV-1-Infected Adults on Antiretroviral Therapy.
Spivak AM, Andrade A, Eisele E, Hoh R, Bacchetti P, Bumpus NN, Emad F, Buckheit R 3rd, McCance-Katz EF, Lai J, Kennedy M, Chander G, Siliciano RF, Siliciano JD, Deeks SG.
Clin Infect Dis. 2014 Mar;58(6):883-90
READ MORE: Testing “Shock and Kill” 

 


 

February 2014

Differential Blood and Mucosal Immune Responses against an HIV-1 Vaccine Administered via Inguinal or Deltoid Injection.
Yang OO, Ibarrondo FJ, Price C, Hultin LE, Elliott J, Hultin PM, Shih R, Hausner MA, Ng HL, Hoffman J, Jamieson BD, Anton PA.
PLoS One. 2014 Feb 18;9(2):e88621
READ MORE: HIV in the Blood and Gut: Exploring the Differences   

Discordance Between Peripheral and Colonic Markers of Inflammation During Suppressive ART.
Dunham RM, Vujkovic-Cvijin I, Yukl SA, Broadhurst MJ, Loke P, Albright RG, Wong JK, Lederman MM, Somsouk M, Hunt PW, Martin JN, Deeks SG, McCune JM.
J Acquir Immune Defic Syndr. 2014 Feb 1;65(2):133-41.  
READ MORE: HIV in the Blood and Gut: Exploring the Differences 

HIV-1 persistence in CD4(+) T cells with stem cell-like properties.
Buzon MJ, Sun H, Li C, Shaw A, Seiss K, Ouyang Z, Martin-Gayo E, Leng J, Henrich TJ, Li JZ, Pereyra F, Zurakowski R, Walker BD, Rosenberg ES, Yu XG, Lichterfeld M.
Nat Med. 2014 Feb;20(2):139-42. doi: 10.1038/nm.3445. Epub 2014 Jan 12.

 


 

January 2014

 

Composition and Function of T Cell Subpopulations Are Slow to Change Despite Effective Antiretroviral Treatment of HIV Disease.
Emu B, Moretto WJ, Hoh R, Krone M, Martin JN, Nixon DF, Deeks SG, McCune JM.
PLoS One. 2014 Jan 21;9(1):e85613
 

[The adaptation of lentiviruses to apes was a crucial step in the origin of HIV-1]. [Article in French]
Etienne L.
Med Sci (Paris). 2014 Jan;30(1):24-6

Susceptibility to CD8 T-Cell-Mediated Killing Influences the Reservoir of Latently HIV-1-Infected CD4 T Cells.
Buzon MJ, Yang Y, Ouyang Z, Sun H, Seiss K, Rogich J, Le Gall S, Pereyra F, Rosenberg ES, Yu XG, Lichterfeld M.
J Acquir Immune Defic Syndr. 2014 Jan 1;65(1):1-9.
READ MORE: Killer Immunity and HIV Reservoirs   

Trans-activation, post-transcriptional maturation, and induction of antibodies to HERV-K (HML-2) envelope transmembrane protein in HIV-1 infection.
Michaud HA, de Mulder M, Sengupta D, Deeks SG, Martin JN, Pilcher CD, Hecht FM, Sacha JB, Nixon DF.
Retrovirology. 2014 Jan 28;11(1):10.
 

Unique characteristics of histone deacetylase inhibitors in reactivation of latent HIV-1 in Bcl-2-transduced primary resting CD4+ T cells.
Shan L, Xing S, Yang HC, Zhang H, Margolick JB, Siliciano RF.
J Antimicrob Chemother. 2014 Jan;69(1):28-33.

A combination HIV reporter virus system for measuring post-entry event efficiency and viral outcome in primary CD4+ T cell subsets.
Tilton CA, Tabler CO, Lucera MB, Marek SL, Haqqani AA, Tilton JC.
J Virol Methods. 2014 Jan;195:164-9.
 

 


 

December 2013

 

Evans VA, Kumar N, Filali A, Procopio FA, Yegorov O, Goulet JP, Saleh S, Haddad EK, da Fonseca Pereira C, Ellenberg PC, Sekaly RP, Cameron PU, Lewin SR.
Myeloid Dendritic Cells Induce HIV-1 Latency in Non-proliferating CD4(+) T Cells.
PLoS Pathog. 2013 Dec;9(12):e1003799.
READ MORE: New Clues to the Nature of HIV Reservoirs
 

Josefsson L, von Stockenstrom S, Faria NR, Sinclair E, Bacchetti P, Killian M, Epling L, Tan A, Ho T, Lemey P, Shao W, Hunt PW, Somsouk M, Wylie W, Douek DC, Loeb L, Custer J, Hoh R, Poole L, Deeks SG, Hecht F, Palmer S.
The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time.
Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4987-96.
READ MORE: New Clues to the Nature of HIV Reservoirs

 

November 2013

 

Hatano H, Strain MC, Scherzer R, Bacchetti P, Wentworth D, Hoh R, Martin JN, McCune JM, Neaton JD, Tracy RP, Hsue PY, Richman DD, Deeks SG.
Increase in 2-long terminal repeat circles and decrease in D-dimer after raltegravir intensification in patients with treated HIV infection: a randomized, placebo-controlled trial.
J Infect Dis. 2013 Nov 1;208(9):1436-42.
READ MORE: Building a Stronger HAART

Feng Y, Forsell MN, Flynn B, Adams W, Loré K, Seder R, Wyatt RT, Karlsson Hedestam GB.
Chemical cross-linking of HIV-1 Env for direct TLR7/8 ligand conjugation compromises recognition of conserved antigenic determinants.
Virology. 2013 Nov;446(1-2):56-65.

Wohlfeiler D, Hecht J, Volk J, Fisher Raymond H, Kennedy T, McFarland W.
How Can We Improve Online HIV and STD Prevention for Men Who Have Sex with Men? Perspectives of Hook-Up Website Owners, Website Users, and HIV/STD Directors.
AIDS Behav. 2013 Nov;17(9):3024-33.

Persaud D, Gay H, Ziemniak C, Chen YH, Piatak M Jr, Chun TW, Strain M, Richman D, Luzuriaga K.
Absence of detectable HIV-1 viremia after treatment cessation in an infant.
N Engl J Med. 2013 Nov 7;369(19):1828-35.

 

October 2013

 

Henrich TJ, Gandhi RT.
Early treatment and HIV-1 reservoirs: a stitch in time?
J Infect Dis. 2013 Oct 15;208(8):1189-93.
READ MORE: New Benefits of Antiretroviral Therapy Uncovered

Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG.
Prospective Antiretroviral Treatment of Asymptomatic, HIV-1 Infected Controllers.
PLoS Pathog. 2013 Oct;9(10):e1003691.
READ MORE: New Benefits of Antiretroviral Therapy Uncovered

 

All-trans-retinoic acid imprints expression of the gut-homing marker α4β7 while suppressing lymph node homing of dendritic cells.
Evans TI, Reeves RK
Clin Vaccine Immunol. 2013 Oct;20(10):1642-6.
 

 

September 2013

 

Breton G, Chomont N, Takata H, Fromentin R, Ahlers J, Filali-Mouhim A, Riou C, Boulassel MR, Routy JP, Yassine-Diab B, Sékaly RP.
Programmed Death-1 Is a Marker for Abnormal Distribution of Naive/Memory T Cell Subsets in HIV-1 Infection.
J Immunol. 2013 Sep 1;191(5):2194-204.
READ MORE: Attacking AIDS by Attacking Inflammation

 

August 2013

 

The mongoose, the pheasant, the pox, and the retrovirus.
Etienne L, Emerman M.
PLoS Biol. 2013;11(8):e1001641.

Lanxon-Cookson EC, Swain JV, Manocheewa S, Smith RA, Maust B, Kim M, Westfall D, Rolland M, Mullins JI.
Factors affecting relative fitness measurements in pairwise competition assays of human immunodeficiency viruses.
J Virol Methods. 2013 Aug 8;194(1-2):7-13.

Tan J, Sattentau QJ.
The HIV-1-containing macrophage compartment: a perfect cellular niche?
Trends Microbiol. 2013 Aug;21(8):405-12.
READ MORE: Exploring New Cell Reservoirs for HIV 

 

Cillo AR, Krishnan A, Mitsuyasu RT, McMahon DK, Li S, Rossi JJ, Zaia JA, Mellors JW.
Plasma viremia and cellular HIV-1 DNA persist despite autologous hematopoietic stem cell transplantation for HIV-related lymphoma.
J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):438-41.

July 2013

 

Balazs AB, Bloom JD, Hong CM, Rao DS, Baltimore D.
Broad protection against influenza infection by vectored immunoprophylaxis in mice.
Nat Biotechnol. 2013 Jul;31(7):647-52.

 

Klatt NR, Chomont N, Douek DC, Deeks SG.
Imune activation and HIV persistence: implications for curative approaches to HIV infection.
Immunol Rev. 2013 Jul;254(1):326-42.
READ MORE: Working Towards a Cure

 

Chang CC, Crane M, Zhou J, Mina M, Post JJ, Cameron BA, Lloyd AR, Jaworowski A, French MA, Lewin SR.
HIV and co-infections.
Immunol Rev. 2013 Jul;254(1):114-42.

Vujkovic-Cvijin I, Dunham RM, Iwai S, Maher MC, Albright RG, Broadhurst MJ, Hernandez RD, Lederman MM, Huang Y, Somsouk M, Deeks SG, Hunt PW, Lynch SV, McCune JM
Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism.
Sci Transl Med. 2013 Jul 10;5(193):193ra91.
READ MORE: Working Towards a Cure  

 

Hatano H, Jain V, Hunt PW, Lee TH, Sinclair E, Do TD, Hoh R, Martin JN, McCune JM, Hecht F, Busch MP, Deeks SG.
Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells.
J Infect Dis. 2013 Jul;208(1):50-6.
READ MORE: Working Towards a Cure  

 

Etienne L, Hahn BH, Sharp PM, Matsen FA, Emerman M.
Gene Loss and Adaptation to Hominids Underlie the Ancient Origin of HIV-1.
Cell Host Microbe. 2013 Jul 17;14(1):85-92.

 

Forsell MN, Soldemo M, Dosenovic P, Wyatt RT, Karlsson MC, Karlsson Hedestam GB.
Independent Expansion of Epitope-Specific Plasma Cell Responses upon HIV-1 Envelope Glycoprotein Immunization.
J Immunol. 2013 Jul 1;191(1):44-51.

 

Sandgren KJ, Smed-Sörensen A, Forsell MN, Soldemo M, Adams WC, Liang F, Perbeck L, Koup RA, Wyatt RT, Karlsson Hedestam GB, Loré K.
Human Plasmacytoid Dendritic Cells Efficiently Capture HIV-1 Envelope Glycoproteins via CD4 for Antigen Presentation.
J Immunol. 2013 Jul 1;191(1):60-9.

 

Kulpa DA, Brehm JH, Fromentin R, Cooper A, Cooper C, Ahlers J, Chomont N, Sékaly RP.
The immunological synapse: the gateway to the HIV reservoir.
Immunol Rev. 2013 Jul;254(1):305-25.
READ MORE: Working Towards a Cure 

 

Mao Y, Wang L, Gu C, Herschhorn A, Désormeaux A, Finzi A, Xiang SH, Sodroski JG.
Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer.
Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12438-43.

 

Kong L, Lee JH, Doores KJ, Murin CD, Julien JP, McBride R, Liu Y, Marozsan A, Cupo A, Klasse PJ, Hoffenberg S, Caulfield M, King CR, Hua Y, Le KM, Khayat R, Deller MC, Clayton T, Tien H, Feizi T, Sanders RW, Paulson JC, Moore JP, Stanfield RL, Burton DR, Ward AB, Wilson IA
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120.
Nat Struct Mol Biol. 2013 Jul;20(7):796-803.

 

Serra-Moreno R, Zimmermann K, Stern LJ, Evans DT.
Tetherin/BST-2 Antagonism by Nef Depends on a Direct Physical Interaction between Nef and Tetherin, and on Clathrin-mediated Endocytosis.
PLoS Pathog. 2013 Jul;9(7):e1003487.
 

Siliciano JD, Siliciano RF.
HIV-1 eradication strategies: design and assessment.
Curr Opin HIV AIDS. 2013 Jul;8(4):318-25.
READ MORE: Working Towards a Cure 

 

June 2013

 

Berro R, Yasmeen A, Abrol R, Trzaskowski B, Abi-Habib S, Grunbeck A, Lascano D, Goddard WA 3rd, Klasse PJ, Sakmar TP, Moore JP.
Use of G-Protein-Coupled and -Uncoupled CCR5 Receptors by CCR5 Inhibitor-Resistant and -Sensitive Human Immunodeficiency Virus Type 1 Variants.
J Virol. 2013 Jun;87(12):6569-81.
READ MORE: Purging Reservoirs of HIV  

 

Henrich TJ, Hu Z, Li JZ, Sciaranghella G, Busch MP, Keating SM, Gallien S, Lin NH, Giguel FF, Lavoie L, Ho VT, Armand P, Soiffer RJ, Sagar M, Lacasce AS, Kuritzkes DR.
Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation.
J Infect Dis. 2013 Jun 1;207(11):1694-702.
READ MORE: Researcher Reports Two HIV Patients Showing No Signs of Virus in Wake of Stem-Cell Transplants
READ MORE: Purging Reservoirs of HIV 

 

Pace M, O'Doherty U.
Hematopoietic stem cells and HIV infection.
J Infect Dis. 2013 Jun 15;207(12):1790-2.

 

Pace MJ, Graf EH, O'Doherty U.
HIV 2-long terminal repeat circular DNA is stable in primary CD4+T Cells.
Virology. 2013 Jun 20;441(1):18-21.
READ MORE: Purging Reservoirs of HIV  

 

Josefsson L, Palmer S, Faria NR, Lemey P, Casazza J, Ambrozak D, Kearney M, Shao W, Kottilil S, Sneller M, Mellors J, Coffin JM, Maldarelli F.
Single Cell Analysis of Lymph Node Tissue from HIV-1 Infected Patients Reveals that the Majority of CD4(+) T-cells Contain One HIV-1 DNA Molecule.
PLoS Pathog. 2013 Jun;9(6):e1003432.

 

Hunt PW, Shulman NS, Hayes TL, Dahl V, Somsouk M, Funderburg NT, McLaughlin B, Landay AL, Adeyemi O, Gilman LE, Clagett B, Rodriguez B, Martin JN, Schacker TW, Shacklett BL, Palmer S, Lederman MM, Deeks SG.
The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial.
Blood. 2013 Jun 6;121(23):4635-46.
READ MORE: Purging Reservoirs of HIV  

 

Shan L, Siliciano RF.
From reactivation of latent HIV-1 to elimination of the latent reservoir: the presence of multiple barriers to viral eradication.
Bioessays. 2013 Jun;35(6):544-52.
READ MORE: Purging Reservoirs of HIV  

 

Shan L, Rabi SA, Laird GM, Eisele EE, Zhang H, Margolick JB, Siliciano RF.
A novel PCR assay for quantification of HIV-1 RNA.
J Virol. 2013 Jun;87(11):6521-5.
READ MORE: Purging Reservoirs of HIV  

 


May 2013

 

Yukl SA, Boritz E, Busch M, Bentsen C, Chun TW, Douek D, Eisele E, Haase A, Ho YC, Hütter G, Justement JS, Keating S, Lee TH, Li P, Murray D, Palmer S, Pilcher C, Pillai S, Price RW, Rothenberger M, Schacker T, Siliciano J, Siliciano R, Sinclair E, Strain M, Wong J, Richman D, Deeks SG.
Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient.
PLoS Pathog. 2013 May;9(5):e1003347.
READ MORE: Multi-Targeted Approaches to an HIV Cure 

 

Vandergeeten C, Fromentin R, Dafonseca S, Lawani MB, Sereti I, Lederman MM, Ramgopal M, Routy JP, Sékaly RP, Chomont N.
Interleukin-7 promotes HIV persistence during antiretroviral therapy.
Blood. 2013 May 23;121(21):4321-9.

 

Bartholomeeusen K, Fujinaga K, Xiang Y, Peterlin BM.
Histone Deacetylase Inhibitors (HDACis) That Release the Positive Transcription Elongation Factor b (P-TEFb) from Its Inhibitory Complex Also Activate HIV Transcription.
J Biol Chem. 2013 May 17;288(20):14400-7.
READ MORE: Multi-Targeted Approaches to an HIV Cure   

 

Hatano H.
Immune activation and HIV persistence: considerations for novel therapeutic interventions.
Curr Opin HIV AIDS. 2013 May;8(3):211-6.
READ MORE: Multi-Targeted Approaches to an HIV Cure   

 

Stone D, Kiem HP, Jerome KR.
Targeted gene disruption to cure HIV.
Curr Opin HIV AIDS. 2013 May;8(3):217-23.
READ MORE: Multi-Targeted Approaches to an HIV Cure 

 

Walsh AD, Bimber BN, Das A, Piaskowski SM, Rakasz EG, Bean AT, Mudd PA, Ericsen AJ, Wilson NA, Hughes AL, O'Connor DH, Maness NJ.
Acute Phase CD8+ T Lymphocytes against Alternate Reading Frame Epitopes Select for Rapid Viral Escape during SIV Infection.
PLoS One. 2013 May 6;8(5):e61383.

 

Mbonye UR, Gokulrangan G, Datt M, Dobrowolski C, Cooper M, Chance MR, Karn J.
Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4(+) T Lymphocytes.
PLoS Pathog. 2013 May;9(5):e1003338

 


April 2013

 

McNatt MW, Zang T, Bieniasz PD.
Vpu binds directly to tetherin and displaces it from nascent virions.
PLoS Pathog. 2013 Apr;9(4):e1003299.

 

Voit RA, McMahon MA, Sawyer SL, Porteus MH.
Generation of an HIV Resistant T-cell Line by Targeted "Stacking" of Restriction Factors.
Mol Ther. 2013 Apr;21(4):786-95
READ MORE: Stopping HIV Using a Cocktail of Genes Rather than Drugs

 


March 2013

 

Désormeaux A, Coutu M, Medjahed H, Pacheco B, Herschhorn A, Gu C, Xiang SH, Mao Y, Sodroski J, Finzi A.
The highly conserved layer-3 component of the HIV-1 gp120 inner domain is critical for CD4-required conformational transitions.
J Virol. 2013 Mar;87(5):2549-62.

 

Kutluay SB, Perez-Caballero D, Bieniasz PD.
Fates of Retroviral Core Components during Unrestricted and TRIM5-Restricted Infection.
PLoS Pathog. 2013 Mar;9(3):e1003214.
 

Palmer S.
Advances in detection and monitoring of plasma viremia in HIV-infected individuals receiving antiretroviral therapy.
Curr Opin HIV AIDS. 2013 Mar;8(2):87-92. 
READ MORE: Perfecting Tools to Monitor HIV Viral Loads

 


February 2013

 

Dunham RM, Gordon SN, Vaccari M, Piatak M, Huang Y, Deeks SG, Lifson J, Franchini G, McCune JM.
Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: a pilot study testing inhibition of indoleamine 2,3-dioxygenase.
AIDS Res Hum Retroviruses. 2013 Feb;29(2):207-14.
READ MORE: Keeping Track of HIV Reservoirs

 

Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, Bosch RJ, Lai J, Chioma S, Emad F, Abdel-Mohsen M, Hoh R, Hecht F, Hunt P, Somsouk M, Wong J, Johnston R, Siliciano RF, Richman DD, O'Doherty U, Palmer S, Deeks SG, Siliciano JD.
Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies.
PLoS Pathog. 2013 Feb;9(2):e1003174. 
READ MORE: Keeping Track of HIV Reservoirs

 


January 2013

 

Ross MW, Nyoni J, Bowen AM, Williams ML, Kashiha JJ.
Sexual and geographic organization of men who have sex with men in a large East African city: opportunities for outreach.
BMJ Open. 2012 Nov 22;2(6) e001813. 

 

Azzoni L, Foulkes AS, Papasavvas E, Mexas AM, Lynn KM, Mounzer K, Tebas P, Jacobson JM, Frank I, Busch MP, Deeks SG, Carrington M, O'Doherty U, Kostman J, Montaner LJ.
Pegylated Interferon Alfa-2a Monotherapy Results in Suppression of HIV Type 1 Replication and Decreased Cell-Associated HIV DNA Integration.
J Infect Dis. 2013 Jan; 207(2):213-22.
READ MORE: Controlling HIV After Stopping Antiretroviral Therapy