amfAR, The Foundation for AIDS Research

Publications from amfAR Grantees and Fellows (2014 - 2013)

Click here for publications prior to 2013.

Publications of amfAR Grantees and Fellows


Each month, the findings of amfAR-funded researchers (names in bold) are published in peer-reviewed journals, which are listed below by month of publication. In each case you can click on the “ABSTRACT” link for a brief summary of the research paper as it appears in the journal. In some cases, you can click on the "READ MORE" link to access related articles written for a lay audience by amfAR staff. 


January 2014


Emu B, Moretto WJ, Hoh R, Krone M, Martin JN, Nixon DF, Deeks SG, McCune JM.
Composition and Function of T Cell Subpopulations Are Slow to Change Despite Effective Antiretroviral Treatment of HIV Disease.
PLoS One. 2014 Jan 21;9(1):e85613

Buzon MJ, Yang Y, Ouyang Z, Sun H, Seiss K, Rogich J, Le Gall S, Pereyra F, Rosenberg ES, Yu XG, Lichterfeld M.
Susceptibility to CD8 T-Cell-Mediated Killing Influences the Reservoir of Latently HIV-1-Infected CD4 T Cells.
J Acquir Immune Defic Syndr. 2014 Jan 1;65(1):1-9.

Michaud HA, de Mulder M, Sengupta D, Deeks SG, Martin JN, Pilcher CD, Hecht FM, Sacha JB, Nixon DF.
Trans-activation, post-transcriptional maturation, and induction of antibodies to HERV-K (HML-2) envelope transmembrane protein in HIV-1 infection.

Retrovirology. 2014 Jan 28;11(1):10.

Shan L, Xing S, Yang HC, Zhang H, Margolick JB, Siliciano RF.
Unique characteristics of histone deacetylase inhibitors in reactivation of latent HIV-1 in Bcl-2-transduced primary resting CD4+ T cells.

J Antimicrob Chemother. 2014 Jan;69(1):28-33.

Tilton CA, Tabler CO, Lucera MB, Marek SL, Haqqani AA, Tilton JC.
A combination HIV reporter virus system for measuring post-entry event efficiency and viral outcome in primary CD4+ T cell subsets.
J Virol Methods. 2014 Jan;195:164-9.



December 2013


Evans VA, Kumar N, Filali A, Procopio FA, Yegorov O, Goulet JP, Saleh S, Haddad EK, da Fonseca Pereira C, Ellenberg PC, Sekaly RP, Cameron PU, Lewin SR.
Myeloid Dendritic Cells Induce HIV-1 Latency in Non-proliferating CD4(+) T Cells.
PLoS Pathog. 2013 Dec;9(12):e1003799.
READ MORE: New Clues to the Nature of HIV Reservoirs

Josefsson L, von Stockenstrom S, Faria NR, Sinclair E, Bacchetti P, Killian M, Epling L, Tan A, Ho T, Lemey P, Shao W, Hunt PW, Somsouk M, Wylie W, Douek DC, Loeb L, Custer J, Hoh R, Poole L, Deeks SG, Hecht F, Palmer S.
The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time.
Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4987-96.
READ MORE: New Clues to the Nature of HIV Reservoirs


November 2013


Hatano H, Strain MC, Scherzer R, Bacchetti P, Wentworth D, Hoh R, Martin JN, McCune JM, Neaton JD, Tracy RP, Hsue PY, Richman DD, Deeks SG.
Increase in 2-long terminal repeat circles and decrease in D-dimer after raltegravir intensification in patients with treated HIV infection: a randomized, placebo-controlled trial.
J Infect Dis. 2013 Nov 1;208(9):1436-42.
READ MORE: Building a Stronger HAART

Feng Y, Forsell MN, Flynn B, Adams W, Loré K, Seder R, Wyatt RT, Karlsson Hedestam GB.
Chemical cross-linking of HIV-1 Env for direct TLR7/8 ligand conjugation compromises recognition of conserved antigenic determinants.
Virology. 2013 Nov;446(1-2):56-65.

Wohlfeiler D, Hecht J, Volk J, Fisher Raymond H, Kennedy T, McFarland W.
How Can We Improve Online HIV and STD Prevention for Men Who Have Sex with Men? Perspectives of Hook-Up Website Owners, Website Users, and HIV/STD Directors.
AIDS Behav. 2013 Nov;17(9):3024-33.

Persaud D, Gay H, Ziemniak C, Chen YH, Piatak M Jr, Chun TW, Strain M, Richman D, Luzuriaga K.
Absence of detectable HIV-1 viremia after treatment cessation in an infant.
N Engl J Med. 2013 Nov 7;369(19):1828-35.


October 2013


Henrich TJ, Gandhi RT.
Early treatment and HIV-1 reservoirs: a stitch in time?
J Infect Dis. 2013 Oct 15;208(8):1189-93.
READ MORE: New Benefits of Antiretroviral Therapy Uncovered

Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG.
Prospective Antiretroviral Treatment of Asymptomatic, HIV-1 Infected Controllers.
PLoS Pathog. 2013 Oct;9(10):e1003691.
READ MORE: New Benefits of Antiretroviral Therapy Uncovered


September 2013


Breton G, Chomont N, Takata H, Fromentin R, Ahlers J, Filali-Mouhim A, Riou C, Boulassel MR, Routy JP, Yassine-Diab B, Sékaly RP.
Programmed Death-1 Is a Marker for Abnormal Distribution of Naive/Memory T Cell Subsets in HIV-1 Infection.
J Immunol. 2013 Sep 1;191(5):2194-204.
READ MORE: Attacking AIDS by Attacking Inflammation


August 2013


The mongoose, the pheasant, the pox, and the retrovirus.
Etienne L, Emerman M.
PLoS Biol. 2013;11(8):e1001641.

Lanxon-Cookson EC, Swain JV, Manocheewa S, Smith RA, Maust B, Kim M, Westfall D, Rolland M, Mullins JI.
Factors affecting relative fitness measurements in pairwise competition assays of human immunodeficiency viruses.
J Virol Methods. 2013 Aug 8;194(1-2):7-13.

Tan J, Sattentau QJ.
The HIV-1-containing macrophage compartment: a perfect cellular niche?
Trends Microbiol. 2013 Aug;21(8):405-12.
READ MORE: Exploring New Cell Reservoirs for HIV 


Cillo AR, Krishnan A, Mitsuyasu RT, McMahon DK, Li S, Rossi JJ, Zaia JA, Mellors JW.
Plasma viremia and cellular HIV-1 DNA persist despite autologous hematopoietic stem cell transplantation for HIV-related lymphoma.
J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):438-41.

July 2013


Balazs AB, Bloom JD, Hong CM, Rao DS, Baltimore D.
Broad protection against influenza infection by vectored immunoprophylaxis in mice.
Nat Biotechnol. 2013 Jul;31(7):647-52.


Klatt NR, Chomont N, Douek DC, Deeks SG.
Imune activation and HIV persistence: implications for curative approaches to HIV infection.
Immunol Rev. 2013 Jul;254(1):326-42.
READ MORE: Working Towards a Cure


Chang CC, Crane M, Zhou J, Mina M, Post JJ, Cameron BA, Lloyd AR, Jaworowski A, French MA, Lewin SR.
HIV and co-infections.
Immunol Rev. 2013 Jul;254(1):114-42.

Vujkovic-Cvijin I, Dunham RM, Iwai S, Maher MC, Albright RG, Broadhurst MJ, Hernandez RD, Lederman MM, Huang Y, Somsouk M, Deeks SG, Hunt PW, Lynch SV, McCune JM
Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism.
Sci Transl Med. 2013 Jul 10;5(193):193ra91.
READ MORE: Working Towards a Cure  


Hatano H, Jain V, Hunt PW, Lee TH, Sinclair E, Do TD, Hoh R, Martin JN, McCune JM, Hecht F, Busch MP, Deeks SG.
Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells.
J Infect Dis. 2013 Jul;208(1):50-6.
READ MORE: Working Towards a Cure  


Etienne L, Hahn BH, Sharp PM, Matsen FA, Emerman M.
Gene Loss and Adaptation to Hominids Underlie the Ancient Origin of HIV-1.
Cell Host Microbe. 2013 Jul 17;14(1):85-92.


Forsell MN, Soldemo M, Dosenovic P, Wyatt RT, Karlsson MC, Karlsson Hedestam GB.
Independent Expansion of Epitope-Specific Plasma Cell Responses upon HIV-1 Envelope Glycoprotein Immunization.
J Immunol. 2013 Jul 1;191(1):44-51.


Sandgren KJ, Smed-Sörensen A, Forsell MN, Soldemo M, Adams WC, Liang F, Perbeck L, Koup RA, Wyatt RT, Karlsson Hedestam GB, Loré K.
Human Plasmacytoid Dendritic Cells Efficiently Capture HIV-1 Envelope Glycoproteins via CD4 for Antigen Presentation.
J Immunol. 2013 Jul 1;191(1):60-9.


Kulpa DA, Brehm JH, Fromentin R, Cooper A, Cooper C, Ahlers J, Chomont N, Sékaly RP.
The immunological synapse: the gateway to the HIV reservoir.
Immunol Rev. 2013 Jul;254(1):305-25.
READ MORE: Working Towards a Cure 


Mao Y, Wang L, Gu C, Herschhorn A, Désormeaux A, Finzi A, Xiang SH, Sodroski JG.
Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer.
Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12438-43.


Kong L, Lee JH, Doores KJ, Murin CD, Julien JP, McBride R, Liu Y, Marozsan A, Cupo A, Klasse PJ, Hoffenberg S, Caulfield M, King CR, Hua Y, Le KM, Khayat R, Deller MC, Clayton T, Tien H, Feizi T, Sanders RW, Paulson JC, Moore JP, Stanfield RL, Burton DR, Ward AB, Wilson IA
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120.
Nat Struct Mol Biol. 2013 Jul;20(7):796-803.


Serra-Moreno R, Zimmermann K, Stern LJ, Evans DT.
Tetherin/BST-2 Antagonism by Nef Depends on a Direct Physical Interaction between Nef and Tetherin, and on Clathrin-mediated Endocytosis.
PLoS Pathog. 2013 Jul;9(7):e1003487.

Siliciano JD, Siliciano RF.
HIV-1 eradication strategies: design and assessment.
Curr Opin HIV AIDS. 2013 Jul;8(4):318-25.
READ MORE: Working Towards a Cure 


June 2013


Berro R, Yasmeen A, Abrol R, Trzaskowski B, Abi-Habib S, Grunbeck A, Lascano D, Goddard WA 3rd, Klasse PJ, Sakmar TP, Moore JP.
Use of G-Protein-Coupled and -Uncoupled CCR5 Receptors by CCR5 Inhibitor-Resistant and -Sensitive Human Immunodeficiency Virus Type 1 Variants.
J Virol. 2013 Jun;87(12):6569-81.
READ MORE: Purging Reservoirs of HIV  


Henrich TJ, Hu Z, Li JZ, Sciaranghella G, Busch MP, Keating SM, Gallien S, Lin NH, Giguel FF, Lavoie L, Ho VT, Armand P, Soiffer RJ, Sagar M, Lacasce AS, Kuritzkes DR.
Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation.
J Infect Dis. 2013 Jun 1;207(11):1694-702.
READ MORE: Researcher Reports Two HIV Patients Showing No Signs of Virus in Wake of Stem-Cell Transplants
READ MORE: Purging Reservoirs of HIV 


Pace M, O'Doherty U.
Hematopoietic stem cells and HIV infection.
J Infect Dis. 2013 Jun 15;207(12):1790-2.


Pace MJ, Graf EH, O'Doherty U.
HIV 2-long terminal repeat circular DNA is stable in primary CD4+T Cells.
Virology. 2013 Jun 20;441(1):18-21.
READ MORE: Purging Reservoirs of HIV  


Josefsson L, Palmer S, Faria NR, Lemey P, Casazza J, Ambrozak D, Kearney M, Shao W, Kottilil S, Sneller M, Mellors J, Coffin JM, Maldarelli F.
Single Cell Analysis of Lymph Node Tissue from HIV-1 Infected Patients Reveals that the Majority of CD4(+) T-cells Contain One HIV-1 DNA Molecule.
PLoS Pathog. 2013 Jun;9(6):e1003432.


Hunt PW, Shulman NS, Hayes TL, Dahl V, Somsouk M, Funderburg NT, McLaughlin B, Landay AL, Adeyemi O, Gilman LE, Clagett B, Rodriguez B, Martin JN, Schacker TW, Shacklett BL, Palmer S, Lederman MM, Deeks SG.
The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial.
Blood. 2013 Jun 6;121(23):4635-46.
READ MORE: Purging Reservoirs of HIV  


Shan L, Siliciano RF.
From reactivation of latent HIV-1 to elimination of the latent reservoir: the presence of multiple barriers to viral eradication.
Bioessays. 2013 Jun;35(6):544-52.
READ MORE: Purging Reservoirs of HIV  


Shan L, Rabi SA, Laird GM, Eisele EE, Zhang H, Margolick JB, Siliciano RF.
A novel PCR assay for quantification of HIV-1 RNA.
J Virol. 2013 Jun;87(11):6521-5.
READ MORE: Purging Reservoirs of HIV  


May 2013


Yukl SA, Boritz E, Busch M, Bentsen C, Chun TW, Douek D, Eisele E, Haase A, Ho YC, Hütter G, Justement JS, Keating S, Lee TH, Li P, Murray D, Palmer S, Pilcher C, Pillai S, Price RW, Rothenberger M, Schacker T, Siliciano J, Siliciano R, Sinclair E, Strain M, Wong J, Richman D, Deeks SG.
Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient.
PLoS Pathog. 2013 May;9(5):e1003347.
READ MORE: Multi-Targeted Approaches to an HIV Cure 


Vandergeeten C, Fromentin R, Dafonseca S, Lawani MB, Sereti I, Lederman MM, Ramgopal M, Routy JP, Sékaly RP, Chomont N.
Interleukin-7 promotes HIV persistence during antiretroviral therapy.
Blood. 2013 May 23;121(21):4321-9.


Bartholomeeusen K, Fujinaga K, Xiang Y, Peterlin BM.
Histone Deacetylase Inhibitors (HDACis) That Release the Positive Transcription Elongation Factor b (P-TEFb) from Its Inhibitory Complex Also Activate HIV Transcription.
J Biol Chem. 2013 May 17;288(20):14400-7.
READ MORE: Multi-Targeted Approaches to an HIV Cure   


Hatano H.
Immune activation and HIV persistence: considerations for novel therapeutic interventions.
Curr Opin HIV AIDS. 2013 May;8(3):211-6.
READ MORE: Multi-Targeted Approaches to an HIV Cure   


Stone D, Kiem HP, Jerome KR.
Targeted gene disruption to cure HIV.
Curr Opin HIV AIDS. 2013 May;8(3):217-23.
READ MORE: Multi-Targeted Approaches to an HIV Cure 


Walsh AD, Bimber BN, Das A, Piaskowski SM, Rakasz EG, Bean AT, Mudd PA, Ericsen AJ, Wilson NA, Hughes AL, O'Connor DH, Maness NJ.
Acute Phase CD8+ T Lymphocytes against Alternate Reading Frame Epitopes Select for Rapid Viral Escape during SIV Infection.
PLoS One. 2013 May 6;8(5):e61383.


Mbonye UR, Gokulrangan G, Datt M, Dobrowolski C, Cooper M, Chance MR, Karn J.
Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4(+) T Lymphocytes.
PLoS Pathog. 2013 May;9(5):e1003338


April 2013


McNatt MW, Zang T, Bieniasz PD.
Vpu binds directly to tetherin and displaces it from nascent virions.
PLoS Pathog. 2013 Apr;9(4):e1003299.


Voit RA, McMahon MA, Sawyer SL, Porteus MH.
Generation of an HIV Resistant T-cell Line by Targeted "Stacking" of Restriction Factors.
Mol Ther. 2013 Apr;21(4):786-95
READ MORE: Stopping HIV Using a Cocktail of Genes Rather than Drugs


March 2013


Désormeaux A, Coutu M, Medjahed H, Pacheco B, Herschhorn A, Gu C, Xiang SH, Mao Y, Sodroski J, Finzi A.
The highly conserved layer-3 component of the HIV-1 gp120 inner domain is critical for CD4-required conformational transitions.
J Virol. 2013 Mar;87(5):2549-62.


Kutluay SB, Perez-Caballero D, Bieniasz PD.
Fates of Retroviral Core Components during Unrestricted and TRIM5-Restricted Infection.
PLoS Pathog. 2013 Mar;9(3):e1003214.

Palmer S.
Advances in detection and monitoring of plasma viremia in HIV-infected individuals receiving antiretroviral therapy.
Curr Opin HIV AIDS. 2013 Mar;8(2):87-92. 
READ MORE: Perfecting Tools to Monitor HIV Viral Loads


February 2013


Dunham RM, Gordon SN, Vaccari M, Piatak M, Huang Y, Deeks SG, Lifson J, Franchini G, McCune JM.
Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: a pilot study testing inhibition of indoleamine 2,3-dioxygenase.
AIDS Res Hum Retroviruses. 2013 Feb;29(2):207-14.
READ MORE: Keeping Track of HIV Reservoirs


Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, Bosch RJ, Lai J, Chioma S, Emad F, Abdel-Mohsen M, Hoh R, Hecht F, Hunt P, Somsouk M, Wong J, Johnston R, Siliciano RF, Richman DD, O'Doherty U, Palmer S, Deeks SG, Siliciano JD.
Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies.
PLoS Pathog. 2013 Feb;9(2):e1003174. 
READ MORE: Keeping Track of HIV Reservoirs


January 2013


Ross MW, Nyoni J, Bowen AM, Williams ML, Kashiha JJ.
Sexual and geographic organization of men who have sex with men in a large East African city: opportunities for outreach.
BMJ Open. 2012 Nov 22;2(6) e001813. 


Azzoni L, Foulkes AS, Papasavvas E, Mexas AM, Lynn KM, Mounzer K, Tebas P, Jacobson JM, Frank I, Busch MP, Deeks SG, Carrington M, O'Doherty U, Kostman J, Montaner LJ.
Pegylated Interferon Alfa-2a Monotherapy Results in Suppression of HIV Type 1 Replication and Decreased Cell-Associated HIV DNA Integration.
J Infect Dis. 2013 Jan; 207(2):213-22.
READ MORE: Controlling HIV After Stopping Antiretroviral Therapy