Publications from amfAR Grantees and Fellows (2020-2023)
Introduction
Each month, the findings of amfAR-funded researchers (names in bold) are published in peer-reviewed journals, which are listed below by month of publication. In each case you can click on the “ABSTRACT” link for a brief summary of the research paper as it appears in the journal. In some cases, you can click on the “READ MORE” link to access related articles written for a lay audience by amfAR staff.
November 2024
Plant-produced SARS-CoV-2 antibody engineered towards enhanced potency and in vivo efficacy.
de Taeye SW, Faye L, Morel B, Schriek AI, Umotoy JC, Yuan M, Kuzmina NA, Turner HL, Zhu X, Grünwald-Gruber C, Poniman M, Burger JA, Caniels TG, Fitchette AC, Desgagnés R, Stordeur V, Mirande L, Beauverger G, de Bree G, Ozorowski G, Ward AB, Wilson IA, Bukreyev A, Sanders RW, Vezina LP, Beaumont T, van Gils MJ, Gomord V. Plant Biotechnol J. 2024 Nov 19. doi: 10.1111/pbi.14458. Online ahead of print.
Rapid biphasic decay of intact and defective HIV DNA reservoir during acute treated HIV disease.
Barbehenn A, Shi L, Shao J, Hoh R, Hartig HM, Pae V, Sarvadhavabhatla S, Donaire S, Sheikhzadeh C, Milush J, Laird GM, Mathias M, Ritter K, Peluso MJ, Martin J, Hecht F, Pilcher C, Cohen SE, Buchbinder S, Havlir D, Gandhi M, Henrich TJ, Hatano H, Wang J, Deeks SG, Lee SA. Nat Commun. 2024 Nov 18;15(1):9966.
Footprints of innate immune activity during HIV-1 reservoir cell evolution in early-treated infection.
Sun W, Gao C, Gladkov GT, Roseto I, Carrere L, Parsons EM, Gasca-Capote C, Frater J, Fidler S, Yu XG, Lichterfeld M; RIVER Trial Study Group. J Exp Med. 2024 Nov 4;221(11):e20241091. doi: 10.1084/jem.20241091.
Profound reduction of HIV-1 reservoir cells over three decades of antiretroviral therapy started in early infancy.
Vela LC, Carrere L, Naasz C, Kalavacherla S, Tan TS, de Armas L, Gao C, Yu XG, Pahwa SG, Luzuriaga K, Lichterfeld M. JCI Insight. 2024 Nov 14:e186550. doi: 10.1172/jci.insight.186550. Online ahead of print.
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October 2024
Inhibition of HIV-1 replication by nanobodies targeting tetraspanin CD9.
Umotoy JC, Kroon PZ, Man S, van Dort KA, Atabey T, Schriek AI, Dekkers G, Herrera-Carrillo E, Geijtenbeek TBH, Heukers R, Kootstra NA, van Gils MJ, de Taeye SW. iScience. 2024 Sep 13;27(10):110958.
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Functional comparison of Fc-engineering strategies to improve anti-HIV-1 antibody effector functions.
Schriek AI, Falck D, Wuhrer M, Kootstra NA, van Gils MJ, de Taeye SW. Antiviral Res. 2024 Sep 27;231:106015.
September 2024
Galectin-9 Levels as a Potential Predictor of Intact HIV Reservoir Decay.
Serrano-Villar S, Gala A, Bacchetti P, Hoh R, di Germanio C, Cohn LB, Henrich TJ, Hunt PW, Laird GM, Pillai SK, Deeks SG, Peluso MJ. J Infect Dis. 2024 Aug 28:jiae426. doi: 10.1093/infdis/jiae426.
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August 2024
Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivity to broadly neutralizing antibodies.
Parthasarathy D, Pothula KR, Dam KA, Ratnapriya S, Benet HC, Parsons R, Huang X, Sammour S, Janowska K, Harris M, Sacco S, Sodroski J, Bridges MD, Hubbell WL, Acharya P, Herschhorn A. Nat Commun. 2024 Aug 26;15(1):7334.
Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells.
Sáez-Cirión A, Mamez AC, Avettand-Fenoel V, Nabergoj M, Passaes C, Thoueille P, Decosterd L, Hentzien M, Perdomo-Celis F, Salgado M, Nijhuis M, Melard A, Gardiennet E, Lorin V, Monceaux V, Chapel A, Gourves M, Lechartier M, Mouquet H, Wensing A, Picado JM, Yerly S, Rougemont M, Calmy A. Nat Med. 2024 Sep 2. doi: 10.1038/s41591-024-03277-z.
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Afucosylated broadly neutralizing antibodies enhance clearance of HIV-1 infected cells through cell-mediated killing.
de Taeye SW, Schriek AI, Umotoy JC, Grobben M, Burger JA, Sanders RW, Vidarsson G, Wuhrer M, Falck D, Kootstra NA, van Gils MJ. Commun Biol. 2024 Aug 9;7(1):964. doi: 10.1038/s42003-024-06659-8.
July 2024
Priming antibody responses to the fusion peptide in rhesus macaques.
Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Allen JD, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB. NPJ Vaccines. 2024 Jul 12;9(1):126.
SMD9L acts as an antiviral factor against HIV-1 and primate lentiviruses by restricting viral and cellular translation.
Legrand A, Dahoui C, De La Myre Mory C, Noy K, Guiguettaz L, Versapuech M, Loyer C, Pillon M, Wcislo M, Guéguen L, Berlioz-Torrent C, Cimarelli A, Mateo M, Fiorini F, Ricci EP,Etienne L. PLoS Biol. 2024 Jul 3;22(7):e3002696.
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June 2024
Mapping the Evolutionary Space of SARS-CoV-2 Variants to Anticipate Emergence of Subvariants Resistant to COVID-19 Therapeutics.
Rojas Chávez RA, Fili M, Han C, Rahman SA, Bicar IGL, Gregory S, Helverson A, Hu G, Darbro BW, Das J, Brown GD, Haim H. PLoS Comput Biol. 2024 Jun 10;20(6):e1012215.
Impact of variable sampling on estimates of HIV-1 reservoir formation dates.
Kankaka EN, Poon AFY, Quinn TC, Chang LW, Prodger JL, Redd AD. J Infect Dis. 2024 May 31:jiae294. doi: 10.1093/infdis/jiae294. Online ahead of print.
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May 2024
Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity.
Brunet-Ratnasingham E, Morin S, Randolph HE, Labrecque M, Bélair J, Lima-Barbosa R, Pagliuzza A, Marchitto L, Hultström M, Niessl J, Cloutier R, Sreng Flores AM, Brassard N, Benlarbi M, Prévost J, Ding S, Anand SP, Sannier G, Marks A, Wågsäter D, Bareke E, Zeberg H, Lipcsey M, Frithiof R, Larsson A, Zhou S, Nakanishi T, Morrison D, Vezina D, Bourassa C, Gendron-Lepage G, Medjahed H, Point F, Richard J, Larochelle C, Prat A, Cunningham JL, Arbour N, Durand M, Richards JB, Moon K, Chomont N, Finzi A, Tétreault M, Barreiro L, Wolf G, Kaufmann DE. Nat Commun. 2024 May 16;15(1):4177.
Dynamics of virological and immunological markers of HIV persistence after allogeneic haematopoietic stem-cell transplantation in the IciStem cohort: a prospective observational cohort study. Salgado M, Gálvez C, Nijhuis M, Kwon M, Cardozo-Ojeda EF, Badiola J, Gorman MJ, Huyveneers LEP, Urrea V, Bandera A, Jensen BO, Vandekerckhove L, Jurado M, Raj K, Schulze Zur Wiesch J, Bailén R, Eberhard JM, Nabergoj M, Hütter G, Saldaña-Moreno R, Oldford S, Barrett L, Ramirez MLM, Garba S, Gupta RK, Revollo B, Ferra-Coll C, Kuball J, Alter G, Sáez-Cirión A, Diez-Martin JL, Duke ER, Schiffer JT, Wensing A, Martinez-Picado J; IciStem Consortium.Lancet HIV. 2024 Jun;11(6):e389-e405.
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April 2024
Rapid biphasic decay of intact and defective HIV DNA reservoir during acute treated HIV disease
Barbehenn A, Shi L, Shao J, Hoh R, Hartig HM, Pae V, Sarvadhavabhatla S, Donaire S, Sheikhzadeh C, Milush J, Laird GM, Mathias M, Ritter K, Peluso M, Martin J, Hecht F, Pilcher C, Cohen SE,
Buchbinder S, Havlir D, Gandhi M, Henrich TJ, Hatano H, Wang J, Deeks SG, Lee SA. Rapid Biphasic Decay of Intact and Defective HIV DNA Reservoir During Acute Treated HIV Disease. medRxiv [Preprint]. 2024 Mar 28:2024.03.27.24304867. doi: 10.1101/2024.03.27.24304867.
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March 2024
Effective and targeted latency reversal in CD4(+) T cells from individuals on long term combined antiretroviral therapy initiated during chronic HIV-1 infection.
Ngo MH, Pankrac J, Ho RCY, Ndashimye E, Pawa R, Ceccacci R, Biru T, Olabode AS, Klein K, Li Y, Kovacs C, Assad R, Jacobson JM, Canaday DH, Tomusange S, Jamiru S, Anok A, Kityamuweesi T, Buule P, Galiwango RM, Reynolds SJ, Quinn TC, Redd AD, Prodger JL, Mann JFS, Arts EJ. Emerg Microbes Infect. 2024 Dec;13(1):2327371.
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Influence of Amino Acid Substitutions in Capsid Proteins of Coxsackievirus B5 on Free Chlorine and Thermal Inactivation.
Torii S, Gouttenoire J, Kumar K, Antanasijevic A, Kohn T. Environ Sci Technol. 2024 Mar 26;58(12):5279-5289. doi: 10.1021/acs.est.3c10409. Epub 2024 Mar 15.
Stem cell-derived CAR T cells show greater persistence, trafficking, and viral control compared to ex vivo transduced CAR T cells.
Carrillo MA, Zhen A, Mu W, Rezek V, Martin H, Peterson CW, Kiem HP, Kitchen SG. Mol Ther. 2024 Feb 27:S1525-0016(24)00095-9. doi: 10.1016/j.ymthe.2024.02.026.
February 2024
Participant experiences in a combination HIV cure-related trial with extended analytical treatment interruption in San Francisco, United States
Dubé K, Ndukwe SO, Korolkova A, Dee L, Sugarman J, Sauceda JA. HIV Res Clin Pract. 2024 Jan 29;25(1):2312318. Epub 2024 Feb 13. PMID: 38348830.
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January 2024
Safety and virologic impact of haploidentical NK cells plus IL-2 or N-803 in HIV infection.
Miller JS, Rhein J, Davis ZB, Cooley S, McKenna D, Anderson J, Escandón K, Wieking G, Reichel J,
Thorkelson A, Jorstad S, Safrit JT, Soon-Shiong P, Beilman GJ, Chipman JG, Schacker TW. J Infect Dis. 2024 Jan 11:jiad578. doi: 10.1093/infdis/jiad578. Epub ahead of print. PMID: 38207119.
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December 2023
IL-15-dependent immune crosstalk between natural killer cells and dendritic cells in HIV-1 elite controllers.
Hartana CA, Lancien M, Gao C, Rassadkina Y, Lichterfeld M, Yu XG. Cell Rep. 2023 Dec 26;42(12):113530. doi: 10.1016/j.celrep.2023.113530. Epub 2023 Dec 3.
November 2023
Plasma SARS-CoV-2 RNA elimination and RAGE kinetics distinguish COVID-19 severity.
Deng X, Gantner P, Forestell J, Pagliuzza A, Brunet-Ratnasingham E, Durand M, Kaufmann DE, Chomont N, Craig M. Clin Transl Immunology. 2023 Nov 23;12(11): e1468. doi: 10.1002/cti2.1468.
Persistence of intact HIV-1 proviruses in the brain during antiretroviral therapy.
Sun W, Rassadkina Y, Gao C, Collens SI, Lian X, Solomon IH, Mukerji SS, Yu XG, Lichterfeld M. eLife. 2023 Nov 8; 12:RP89837.
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A flow cytometry-based assay to investigate HIV-1 expression in SMYD5 shRNA containing primary CD4+ T cells.
Boehm D, Ott M. STAR Protoc. 2023 Nov 4;4(4):102694.
Protocol for an in vitro assay to study HIV-1 Tat methylation.
Boehm D, Kaehlcke K, Schnoelzer M, Ott M. STAR Protoc. 2023 Nov 17;4(4):102687.
October 2023
Vertical transmission of SARS-CoV-2-specific antibodies and cytokine profiles in pregnancy.
Monroe JM, Quach HQ, Punia S, Enninga EAL, Fedyshyn Y, Girsch JH, Fedyshyn B, Lemens M, Littlefield D, Behl S, Sintim-Aboagye E, Mejia Plazas MC, Yamaoka S, Ebihara H, Pandey A, Correia C, Ung CY, Li H, Vassallo R, Sun J, Johnson EL, Olson JE, Theel ES, Badley AD, Kennedy RB, Theiler RN, Chakraborty R. J Infect Dis. 2023 Oct 3:jiad399. doi: 10.1093/infdis/jiad399.
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September 2023
Breaching the blood-brain barrier: AAV triggers dose-dependent toxicity in the brain.
Stone D, Aubert M, Jerome KR. Mol Ther Methods Clin Dev. 2023 Sep 20;31:101105.
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August 2023
Strategies for enhancing CAR T cell expansion and persistence in HIV infection.
Rothemejer FH, Lauritsen NP, Sogaard OS, Tolstrup M. Front Immunol. 2023 Aug 21; 14:1253395.
doi:10.3389/fimmun.2023.1253395
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July 2023
Impact of HIV-1 Vpu-mediated downregulation of CD48 on NK-cell-mediated antibody-dependent cellular cytotoxicity.
Marchitto L, Benlarbi M, Prévost J, Laumaea A, Descôteaux-Dinelle J, Medjahed H, Bourassa C, Gendron-Lepage G, Kirchhoff F, Sauter D, Hahn BH, Finzi A, Richard J.
mBio. 2023 Jul 5:e0078923. doi: 10.1128/mbio.00789-23.
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June 2023
A classification algorithm based on dynamic ensemble selection to predict mutational patterns of the envelope protein in HIV-infected patients.
Fili M, Hu G, Han C, Kort A, Trettin J, Haim H. Algorithms Mol Biol. 2023 Jun 19;18(1):4.
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May 2023
Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies.
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Müller-Kräuter H, Müller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB. Cell Rep. 2023 May 30;42(5):112524.
A Multifunctional and Highly Adaptable Reporter System for CRISPR/Cas Editing.
Wettengel JM, Hansen-Palmus L, Yusova S, Rust L, Biswas S, Carson J, Ryu J, Bimber BN, Hennebold JD, Burwitz BJ. Int J Mol Sci. 2023 May 5;24(9):8271.
Adeno-associated virus vectors and neurotoxicity-lessons from preclinical and human studies.
Stone D, Aubert M, Jerome KR. Gene Ther. 2023 May 10. doi: 10.1038/s41434-023-00405-1.
Autologous neutralizing antibodies increase with early antiretroviral therapy and shape HIV rebound after treatment interruption.
Esmaeilzadeh E, Etemad B, Lavine CL, Garneau L, Li Y, Regan J, Wong C, Sharaf R, Connick E, Volberding P, Sagar M, Seaman MS, Li JZ. Sci Transl Med. 2023 May 10;15(695):eabq4490. doi: 10.1126/scitranslmed.abq4490.
Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques.
Wu HL, Busman-Sahay K, Weber WC, Waytashek CM, Boyle CD, Bateman KB, Reed JS, Hwang JM, Shriver-Munsch C, Swanson T, Northrup M, Armantrout K, Price H, Robertson-LeVay M, Uttke S, Kumar MR, Fray EJ, Taylor-Brill S, Bondoc S, Agnor R, Junell SL, Legasse AW, Moats C, Bochart RM, Sciurba J, Bimber BN, Sullivan MN, Dozier B, MacAllister RP, Hobbs TR, Martin LD, Panoskaltsis-Mortari A, Colgin LMA, Siliciano RF, Siliciano JD, Estes JD, Smedley JV, Axthelm MK, Meyers G, Maziarz RT, Burwitz BJ, Stanton JJ, Sacha JB. Immunity. 2023 May 13:S1074-7613(23)00216-9. doi: 10.1016/j.immuni.2023.04.019.
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April 2023
Circulating proteins to predict COVID-19 severity.
Su CY, Zhou S, Gonzalez-Kozlova E, Butler-Laporte G, Brunet-Ratnasingham E, Nakanishi T, Jeon W, Morrison DR, Laurent L, Afilalo J, Afilalo M, Henry D, Chen Y, Carrasco-Zanini J, Farjoun Y, Pietzner M, Kimchi N, Afrasiabi Z, Rezk N, Bouab M, Petitjean L, Guzman C, Xue X, Tselios C, Vulesevic B, Adeleye O, Abdullah T, Almamlouk N, Moussa Y, DeLuca C, Duggan N, Schurr E, Brassard N, Durand M, Del Valle DM, Thompson R, Cedillo MA, Schadt E, Nie K, Simons NW, Mouskas K, Zaki N, Patel M, Xie H, Harris J, Marvin R, Cheng E, Tuballes K, Argueta K, Scott I; Mount Sinai COVID-19 Biobank Team; Greenwood CMT, Paterson C, Hinterberg MA, Langenberg C, Forgetta V, Pineau J, Mooser V, Marron T, Beckmann ND, Kim-Schulze S, Charney AW, Gnjatic S, Kaufmann DE, Merad M, Richards JB. Sci Rep. 2023 Apr 17;13(1):6236.
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A feasibility study for quantitative assessment of cerebrovascular malformations using flutriciclamide ([18F]GE-180) PET/MRI.
Kim SJW, Lupo JM, Chen Y, Pampaloni MH, VanBrocklin HF, Narvid J, Kim H, Seo Y.Front Med (Lausanne). 2023 Apr 5;10:1091463.
March 2023
Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains.
Wang JYJ, Khmelinskaia A, Sheffler W, Miranda MC, Antanasijevic A, Borst AJ, Torres SV, Shu C, Hsia Y, Nattermann U, Ellis D, Walkey C, Ahlrichs M, Chan S, Kang A, Nguyen H, Sydeman C, Sankaran B, Wu M, Bera AK, Carter L, Fiala B, Murphy M, Baker D, Ward AB, King NP. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2214556120.
SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes.
Schaub JA, AlAkwaa FM, McCown PJ, Naik AS, Nair V, Eddy S, Menon R, Otto EA, Demeke D, Hartman J, Fermin D, O’Connor CL, Subramanian L, Bitzer M, Harned R, Ladd P, Pyle L, Pennathur S, Inoki K, Hodgin JB, Brosius FC 3rd, Nelson RG, Kretzler M, Bjornstad P. J Clin Invest. 2023 Mar 1;133(5):e164486.
HIV post-treatment controllers have distinct immunological and virological features.
Etemad B, Sun X, Li Y, Melberg M, Moisi D, Gottlieb R, Ahmed H, Aga E, Bosch RJ, Acosta EP, Yuki Y, Martin MP, Carrington M, Gandhi RT, Jacobson JM, Volberding P, Connick E, Mitsuyasu R, Frank I, Saag M, Eron JJ, Skiest D, Margolis DM, Havlir D, Schooley RT, Lederman MM, Yu XG, Li JZ. Proc Natl Acad Sci U S A. 2023 Mar 4;120(11):e2218960120.
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The lysine methyltransferase SMYD5 amplifies HIV-1 transcription and is post-transcriptionally upregulated by Tat and USP11.
Boehm D, Lam V, Schnolzer M, Ott M. Cell Rep. 2023 Mar 28;42(3):112234.
February 2023
HIV rapidly targets a diverse pool of CD4+ T cells to establish productive and latent infections.
Gantner P, Buranapraditkun S, Pagliuzza A, Dufour C, Pardons M, Mitchell JL, Kroon E, Sacdalan C, Tulmethakaan N, Pinyakorn S, Robb ML, Phanuphak N, Ananworanich J, Hsu D, Vasan S, Trautmann L, Fromentin R, Chomont N. Immunity. 2023 Feb 10:S1074-7613(23)00042-0. doi: 10.1016/j.immuni.2023.01.030.
HIV silencing and cell survival signatures in infected T cell reservoirs.
Clark IC, Mudvari P, Thaploo S, Smith S, Abu-Laban M, Hamouda M, Theberge M, Shah S, Ko SH, Pérez L, Bunis DG, Lee JS, Kilam D, Zakaria S, Choi S, Darko S, Henry AR, Wheeler MA, Hoh R, Butrus S, Deeks SG, Quintana FJ, Douek DC, Abate AR, Boritz EA.Nature. 2023 Feb;614(7947):318-325.
In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation.
Jensen BO, Knops E, Cords L, Lübke N, Salgado M, Busman-Sahay K, Estes JD, Huyveneers LEP, Perdomo-Celis F, Wittner M, Gálvez C, Mummert C, Passaes C, Eberhard JM, Münk C, Hauber I, Hauber J, Heger E, De Clercq J, Vandekerckhove L, Bergmann S, Dunay GA, Klein F, Häussinger D, Fischer JC, Nachtkamp K, Timm J, Kaiser R, Harrer T, Luedde T, Nijhuis M, Sáez-Cirión A, Schulze Zur Wiesch J, Wensing AMJ, Martinez-Picado J, Kobbe G. Nat Med. 2023 Feb 20. doi: 10.1038/s41591-023-02213-x.
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A multiplexed barcode approach to simultaneously evaluate gene delivery by adeno-associasted virus capsid variants in nonhuman primates.
Stone D, Meumann N, Kuhlmann A-S, Peterson CW, Xie H, Roychoudhury P, Loprieno MA, Vu X-K, Strongin DE, Kenkel EJ, Haick A, Stensland L, Obenza WM, Perrott J, Nelson V, Murnane RD, Huang M-L, Aubert M, Kiem H-P, Buning H, Jerome KR. Hepatol Comm. 2023. 7:e0009.
January 2023
Phenotypic signatures of immune selection in HIV-1 reservoir cells.
Sun W, Gao C, Hartana CA, Osborn MR, Einkauf KB, Lian X, Bone B, Bonheur N, Chun TW,
Rosenberg ES, Walker BD, Yu XG, Lichterfeld M. Nature. 2023 Jan 4. doi: 10.1038/s41586-022-05538-8.
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Viral competition assay to assess the role of HIV-1 proteins in immune evasion.
Duette G, Cronin S, Kelleher AD, Palmer S.STAR Protocols 2023;4:102025.
December 2022
HIV-1 reservoir evolution in infants infected with clade C from Mozambique.
Koofhethile CK, Rinaldi S, Rassadkina Y, Dinh VB, Gao C, Pallikkuth S, Garcia-Broncano P, de Armas LR, Pahwa R, Cotugno N, Vaz P, Lain MG, Palma P, Yu XG, Shapiro R, Pahwa S, Lichterfeld M. Int J Infect Dis. 2022 Dec 5;127:129-136.
Cooperation between cGAS and RIG-I sensing pathways enables improved innate recognition of HIV-1 by myeloid dendritic cells in elite controllers.
Martin-Gayo E, Gao C, Calvet-Mirabent M, Ouyang Z, Lichterfeld M, Yu XG. Front Immunol. 2022 Dec 7;13:1017164.
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Progressive transformation of the HIV-1 reservoir cell profile over two decades of antiviral therapy.
Lian X, Seiger KW, Parsons EM, Gao C, Sun W, Gladkov GT, Roseto IC, Einkauf KB, Osborn MR, Chevalier JM, Jiang C, Blackmer J, Carrington M, Rosenberg ES, Lederman MM, McMahon DK, Bosch RJ, Jacobson JM, Gandhi RT, Peluso MJ, Chun TW, Deeks SG, Yu XG, Lichterfeld M. Cell Host Microbe. 2022 Dec 28:S1931-3128(22)00574-1. doi: 10.1016/j.chom.2022.12.002.
November 2022
Lassa virus glycoprotein nanoparticles elicit neutralizing antibody responses and protection.
Brouwer PJM, Antanasijevic A, Ronk AJ, Müller-Kräuter H, Watanabe Y, Claireaux M, Perrett HR, Bijl TPL, Grobben M, Umotoy JC, Schriek AI, Burger JA, Tejjani K, Lloyd NM, Steijaert TH, van Haaren MM, Sliepen K, de Taeye SW, van Gils MJ, Crispin M, Strecker T, Bukreyev A, Ward AB, Sanders RW. Cell Host Microbe. 2022 Nov 17:S1931-3128(22)00531-5. doi: 10.1016/j.chom.2022.10.018.
Stable HIV reservoir despite prolonged low-dose mycophenolate to limit CD4+ T cell proliferation.
Schiffer JT, Levy C, Hughes SM, Pandey U, Padullo M, Jerome KR, Zhu H, Puckett K, Helgeson E, Harrington RD, Hladik F. Open Forum Infect Dis. 2022. Doi: 10.1093/ofid/ofac620.
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Fine-mapping the immunodominant antibody epitopes on consensus sequence-based HIV-1 envelope trimer vaccine candidates.
Reiss EIMM, van Haaren MM, van Schooten J, Claireaux MAF, Maisonnasse P, Antanasijevic A, Allen JD, Bontjer I, Torres JL, Lee WH, Ozorowski G, Vázquez Bernat N, Kaduk M, Aldon Y, Burger JA, Chawla H, Aartse A, Tolazzi M, Gao H, Mundsperger P, Crispin M, Montefiori DC, Karlsson Hedestam GB, Scarlatti G, Ward AB, Le Grand R, Shattock R, Dereuddre-Bosquet N, Sanders RW, van Gils MJ. NPJ Vaccines. 2022 Nov 25;7(1):152. doi: 10.1038/s41541-022-00576-9.
High-resolution structural analysis of enterovirus-reactive polyclonal antibodies in complex with whole virions.
Antanasijevic A, Schulze AJ, Reddy VS, Ward AB.PNAS Nexus. 2022 Nov 4;1(5):pgac253.
Cell-to-cell transmission of HIV-1 from provirus-activated cells to resting naïve and memory human primary CD4 T cells is highly efficient and requires CD4 and F-actin but not chemokine receptors.
Lan J, Li W, Yu R, Syed F, Yu Q.J Med Virol. 2022 Nov;94(11):5434-5450.
October 2022
Memory CD4+ T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency.
Rasmussen TA, Zerbato JM, Rhodes A, Tumpach C, Dantanarayana A, McMahon JH, Lau JSY, Chang JJ, Gubser C, Brown W, Hoh R, Krone M, Pascoe R, Chiu CY, Bramhall M, Lee HJ, Haque A, Fromentin R, Chomont N, Milush J, Van der Sluis RM, Palmer S, Deeks SG, Cameron PU, Evans V, Lewin SR. Cell Rep Med. 2022 Oct 18;3(10):100766. doi: 10.1016/j.xcrm.2022.100766.
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September 2022
Autopsy Study Defines Composition and Dynamics of the HIV–1 Reservoir after Allogeneic Hematopoietic Stem Cell Transplantation with CCR5Δ32/Δ32 Donor Cells.
Huyveneers LEP, Bruns A, Stam A, Ellerbroek P, de Jong D, Nagy NA, Gumbs SBH, Tesselaar K,
Bosman K, Salgado M, Hütter G, Brosens LAA, Kwon M, Diez Martin J, van der Meer JTM, de Kort TM, Sáez-Cirión A, Schulze Zur Wiesch J, Boelens JJ, Martinez-Picado J, Kuball JHE, Wensing AMJ, Nijhuis M; IciStem Consortium.Viruses. 2022 Sep 17;14(9):2069.
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August 2022
Potentiation of drug toxicity through virus latency reversal promotes preferential elimination of HIV infected cells.
Truong TT, Hayn M, Frich CK, Olari L-R, Ladefoged K, Olesen MTJ, Jakobsen JH, Lunabjerg-Vestergaard CK, Schiott B, Munch J, Zelikin AN. Advanced Therapeutics. 2022 doi.10.1002/adtp.202200113.
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July 2022
A mRNA Vaccine Encoding for a RBD 60-mer Nanoparticle Elicits Neutralizing Antibodies and Protective Immunity Against the SARS-CoV-2 Delta Variant in Transgenic K18-hACE2 Mice.
Brandys P, Montagutelli X, Merenkova I, Barut GT, Thiel V, Schork NJ, Trüeb B, Conquet L, Deng A, Antanasijevic A, Lee HK, Valière M, Sindhu A, Singh G, Herold J. Front Immunol. 2022 Jul 6;13:912898. doi: 10.3389/fimmu.2022.912898.
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SARS-CoV-2 and influenza coinfection throughout the COVID-19 pandemic: an assessment of coinfection rates, cohort characteristics, and clinical outcomes.
Pawlowski C, Silvert E, O’Horo JC, Lenehan PJ, Challener D, Gnass E, Murugadoss K, Ross J, Speicher L, Geyer H, Venkatakrishnan AJ, Badley AD, Soundararajan V. PNAS Nexus. 2022 Jul 4;1(3):pgac071. doi: 10.1093/pnasnexus/pgac071.
June 2022
Commonly Elicited Antibodies against the Base of the HIV-1 Env Trimer Guide the Population-Level Evolution of a Structure-Regulating Region in gp41.
Rojas Chávez RA, Boyt D, Schwery N, Han C, Wu L, Haim H.J Virol. 2022 Jun 6:e0040622. doi: 10.1128/jvi.00406-22.
Inhibition of a Chromatin and Transcription Modulator, SLTM, Increases HIV-1 Reactivation Identified by a CRISPR Inhibition Screen.
Pedersen SF, Collora JA, Kim RN, Yang K, Razmi A, Catalano AA, Yeh YJ, Mounzer K, Tebas P, Montaner LJ, Ho YC.J Virol. 2022 Jun 22:e0057722. doi: 10.1128/jvi.00577-22.
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May 2022
Structural mapping of antibody landscapes to human betacoronavirus spike proteins.
Bangaru S, Antanasijevic A, Kose N, Sewall LM, Jackson AM, Suryadevara N, Zhan X, Torres JL, Copps J, de la Peña AT, Crowe JE Jr, Ward AB. Sci Adv. 2022 May 6;8(18):eabn2911. doi: 10.1126/sciadv.abn2911.
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April 2022
Viral and Host Biomarkers of HIV Remission Post Treatment Interruption.
Giron LB, Abdel-Mohsen M. Curr HIV/AIDS Rep. 2022 Apr 19. doi: 10.1007/s11904-022-00607-z. Online ahead of print.
A functional map of HIV-host interactions in primary human T cells.
Hiatt J, Hultquist JF, McGregor MJ, Bouhaddou M, Leenay RT, Simons LM, Young JM, Haas P, Roth TL, Tobin V, Wojcechowskyj JA, Woo JM, Rathore U, Cavero DA, Shifrut E, Nguyen TT, Haas KM, Malik HS, Doudna JA, May AP, Marson A, Krogan NJ. Nat Commun. 2022 Apr 1;13(1):1752.
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March 2022
Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus-infected rhesus macaques on antiretroviral therapy.
Varco-Merth BD, Brantley W, Marenco A, Duell DD, Fachko DN, Richardson B, Busman-Sahay K, Shao D, Flores W, Engelman K, Fukazawa Y, Wong SW, Skalsky RL, Smedley J, Axthelm MK, Lifson JD, Estes JD, Edlefsen PT, Picker L, Cameron CM, Henrich TJ, Okoye AA. J Clin Invest. 2022 Mar 22:e156063. doi: 10.1172/JCI156063.
First-in-human immunoPET imaging of HIV-1 infection using (89)Zr-labeled VRC01 broadly neutralizing antibody.
Beckford-Vera DR, Flavell RR, Seo Y, Martinez-Ortiz E, Aslam M, Thanh C, Fehrman E, Pardons M, Kumar S, Deitchman AN, Ravanfar V, Schulte B, Wu IK, Pan T, Reeves JD, Nixon CC, Iyer NS, Torres L, Munter SE, Hyunh T, Petropoulos CJ, Hoh R, Franc BL, Gama L, Koup RA, Mascola JR, Chomont N, Deeks SG, VanBrocklin HF, Henrich TJ. Nat Commun. 2022 Mar 9;13(1):1219.
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Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones.
Collora JA, Liu R, Pinto-Santini D, Ravindra N, Ganoza C, Lama JR, Alfaro R, Chiarella J, Spudich S, Mounzer K, Tebas P, Montaner LJ, van Dijk D, Duerr A, Ho YC. Immunity. 2022 Mar 17:S1074-7613(22)00127-3. doi: 10.1016/j.immuni.2022.03.004.
Antigenic analysis of the HIV-1 envelope trimer implies small differences between structural states 1 and 2.
Cale EM, Driscoll JI, Lee M, Gorman J, Zhou T, Lu M, Geng H, Lai YT, Chuang GY, Doria-Rose NA, Mothes W, Kwong PD, Mascola JR. J Biol Chem. 2022 Mar 10:101819. doi: 10.1016/j.jbc.2022.101819.
February 2022
The HIV-1 proviral landscape reveals Nef contributes to HIV-1 persistence in effector memory CD4+ T-cells.
Duette G, Hiener B, Morgan H, Mazur FG, Mathivanan V, Horsburgh BA, Fisher K, Tong O, Lee E, Ahn H, Shaik A, Fromentin R, Hoh R, Bacchus-Souffan C, Nasr N, Cunningham A, Hunt PW, Chomont N, Turville SG, Deeks SG, Kelleher AD, Schlub TE, Palmer S. J Clin Invest. 2022 Feb 8:e154422. doi: 10.1172/JCI154422.
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January 2022
Latency reversal plus natural killer cells diminish HIV reservoir in vivo
Kim JT, Zhang TH, Carmona C, Lee B, Seet CS, Kostelny M, Shah N, Chen H, Farrell K, Soliman MSA, Dimapasoc M, Sinani M, Blanco KYR, Bojorquez D, Jiang H, Shi Y, Du Y, Komarova NL, Wodarz D, Wender PA, Marsden MD, Sun R, Zack JA. Nat Commun. 2022 Jan 10;13(121). doi: 10.1038/s41467-021-27647-0.
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From structure to sequence: Antibody discovery using cryoEM.
Antanasijevic A, Bowman CA, Kirchdoerfer RN, Cottrell CA, Ozorowski G, Upadhyay AA, Cirelli KM, Carnathan DG, Enemuo CA, Sewall LM, Nogal B, Zhao F, Groschel B, Schief WR, Sok D, Silvestri G, Crotty S, Bosinger SE, Ward AB. Sci Adv. 2022 Jan 21;8(3):eabk2039.
Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda.
Joussef-Piña S, Nankya I, Nalukwago S, Baseke J, Rwambuya S, Winner D, Kyeyune F, Chervenak K, Thiel B, Asaad R, Dobrowolski C, Luttge B, Lawley B, Kityo CM, Boom WH, Karn J, Quiñones-Mateu ME. Retrovirology. 2022 Jan 15;19(1):1.
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ApoA-I mimetics reduce systemic and gut inflammation in chronic treated HIV.
Daskou M, Mu W, Sharma M, Vasilopoulos H, Heymans R, Ritou E, Rezek V, Hamid P, Kossyvakis A, Sen Roy S, Grijalva V, Chattopadhyay A, Kitchen SG, Fogelman AM, Reddy ST, Kelesidis T. PLoS Pathog. 2022 Jan 7;18(1):e1010160.
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Combination Immune Checkpoint Blockade Enhances IL-2 and CD107a Production from HIV-Specific T Cells Ex Vivo in People Living with HIV on Antiretroviral Therapy.
Chiu CY, Chang JJ, Dantanarayana AI, Solomon A, Evans VA, Pascoe R, Gubser C, Trautman L, Fromentin R, Chomont N, McMahon JH, Cameron PU, Rasmussen TA, Lewin SR. J Immunol. 2022 Jan 1;208(1):54-62.
Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses.
Einkauf KB, Osborn MR, Gao C, Sun W, Sun X, Lian X, Parsons EM, Gladkov GT, Seiger KW, Blackmer JE, Jiang C, Yukl SA, Rosenberg ES, Yu XG, Lichterfeld M. Cell. 2022 Jan 20;185(2):266-282.
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Effect of 3BNC117 and romidepsin on the HIV-1 reservoir in people taking suppressive antiretroviral therapy (ROADMAP): a randomised, open-label, phase 2A trial.
Henning Gruell*, Jesper D Gunst*, Yehuda Z Cohen*, Marie H Pahus, Jakob J Malin, Martin Platten, Katrina G Millard, Martin Tolstrup, R Brad Jones, Winnifer D Conce Alberto, Julio C C Lorenzi, Thiago Y Oliveira, Tim Kümmerle, Isabelle Suárez, Cecilia Unson-O’Brien, Lilian Nogueira, Rikke Olesen, Lars Østergaard, Henrik Nielsen, Clara Lehmann, Michel C Nussenzweig, Gerd Fätkenheuer, Florian Klein, Marina Caskey, Ole S Søgaard. Lancet Microbe. Published Online January 24, 2022 https://doi.org/10.1016/ S2666-5247(21)00239-1.
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December 2021
Techniques for Developing and Assessing Immune Responses Induced by Synthetic DNA Vaccines for Emerging Infectious Diseases.
Xu Z, Ho M, Bordoloi D, Kudchodkar S, Khoshnejad M, Giron L, Zaidi F, Jeong M, Roberts CC, Park YK, Maslow J, Abdel-Mohsen M, Muthumani K. Methods Mol Biol. 2022;2410:229-263.
Signatures of immune selection in intact and defective proviruses distinguish HIV-1 elite controllers.
Lian X, Gao C, Sun X, Jiang C, Einkauf KB, Seiger KW, Chevalier JM, Yuki Y, Martin M, Hoh R, Peluso MJ, Carrington M, Ruiz-Mateos E, Deeks SG, Rosenberg ES, Walker BD, Lichterfeld M, Yu XG.Sci Transl Med. 2021 Dec 15;13(624):eabl4097.
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November 2021
Single center, open label dose escalating trial evaluating once weekly oral ixazomib in ART-suppressed, HIV positive adults and effects on HIV reservoir size in vivo.
Cummins NW, Baker J, Chakraborty R, Dean PG, Garcia-Rivera E, Krogman A, Kumar S, Kuzmichev YV, Laird GM, Landay A, Lichterfeld M, Mahmood M, Martinson J, Maynes M, Natesampillai S, Rajkumar V, Rassadkina Y, Ritter KD, Rivera CG, Rizza SA, Subramanian K, Tande AJ, Wonderlich ER, Whitaker JA, Zeuli J, Badley AD. EClinicalMedicine. 2021 Nov 29;42:101225.
Rebound HIV viremia with meningoencephalitis following antiretroviral therapy interruption after allogeneic bone marrow transplant.
Capoferri AA, Redd AD, Gocke CD, Clark LR, Quinn TC, Ambinder RF, Durand CM. J Acquir Immune Defic Syndr. 2021 Nov 8. doi: 10.1097/QAI.0000000000002862.
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Multiscale Approach for Computing Gated Ligand Binding from Molecular Dynamics and Brownian Dynamics Simulations.
Sadiq SK, Muñiz Chicharro A, Friedrich P, Wade RC. J Chem Theory Comput. 2021 Nov 5. doi: 10.1021/acs.jctc.1c00673.
Asymmetric Structures and Conformational Plasticity of the Uncleaved Full-Length Human Immunodeficiency Virus Envelope Glycoprotein Trimer.
Zhang S, Wang K, Wang WL, Nguyen HT, Chen S, Lu M, Go EP, Ding H, Steinbock RT, Desaire H, Kappes JC, Sodroski J, Mao Y. J Virol. 2021 Nov 23;95(24):e0052921.
October 2021
Are We Hitting the Target? HIV Pre-Exposure Prophylaxis from 2012 to 2020 in the OPERA Cohort.
Mounzer KC, Fusco JS, Hsu RK, Brunet L, Vannappagari V, Frost KR, Shaefer MS, Rinehart A, Rawlings K, Fusco GP. AIDS Patient Care STDS. 2021 Oct 4. doi: 10.1089/apc.2021.0064.
Inhibition of the H3K27 demethylase UTX enhances the epigenetic silencing of HIV proviruses and induces HIV-1 DNA hypermethylation but fails to permanently block HIV reactivation.
Nguyen K, Dobrowolski C, Shukla M, Cho WK, Luttge B, Karn J. PLoS Pathog. 2021 Oct 21;17(10):e1010014.
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September 2021
Functional impairment of HIV-specific CD8(+) T cells precedes aborted spontaneous control of viremia.
Collins DR, Urbach JM, Racenet ZJ, Arshad U, Power KA, Newman RM, Mylvaganam GH, Ly NL, Lian X, Rull A, Rassadkina Y, Yanez AG, Peluso MJ, Deeks SG, Vidal F, Lichterfeld M, Yu XG, Gaiha GD, Allen TM, Walker BD. Immunity. 2021 Sep 2:S1074-7613
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The clonal expansion dynamics of the HIV-1 reservoir: mechanisms of integration site-deopendent proliferation and HIV-1 persistence.
Yang-Hui Jimmy Yeh, Kerui Yang, Anya Razmi, Ya-Chi Ho. Viruses. 2021 Sep 13(9)i:1858.
A systems approach to elucidate personalized mechanistic complexities of antibody-Fc receptor activation post-vaccination.
Lemke MM, McLean MR, Lee CY, Lopez E, Bozich ER, Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kratochvil S, Wines BD, Hogarth PM, Kent SJ, Chung AW, Arnold KB.Cell Rep Med. 2021 Sep 1;2(9):100386.
August 2021
Intravenous bamlanivimab use associates with reduced hospitalization in high-risk patients with mild to moderate COVID-19.
Ganesh R, Pawlowski CF, O’Horo JC, Arndt LL, Arndt RF, Bell S, Bierle DM, Destro Borgen M, Hanson S, Heyliger A, Larsen JL, Lenehan PJ, Orenstein R, Puranik A, Speicher LL, Tulledge-Scheitel SM, Venkatakrishnan AJ, Wilker CG, Badley AD, Razonable RR. J Clin Invest. 2021 Aug 19:151697. doi: 10.1172/JCI151697.
Intra- and extra-cellular environments contribute to the fate of HIV-1 infection.
Ratnapriya S, Harris M, Chov A, Herbert ZT, Vrbanac V, Deruaz M, Achuthan V, Engelman AN, Sodroski J, Herschhorn A. Cell Rep. 2021 Aug 31;36(9):109622.
Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein.
van Haaren MM, McCoy LE, Torres JL, Lee W, Cottrell CA, Copps JL, van der Woude P, Yasmeen A, de Taeye SW, Torrents de la Peña A, Moore JP, Burton DR, Klasse PJ, Ward AB, Sanders RW, van Gils MJ. J Virol. 2021 Aug 10;95(17):e0009421. doi: 10.1128/JVI.00094-21.
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July 2021
Association of transcriptomic signatures of inflammatory response with viral control after dendritic cell-based therapeutic vaccination in HIV-1 infecred individuals. Feher C, Pastor-Ibanez R, Leal L, Plana M, Arnedo M, van den Ham H-J, Andeweg AC, Gruters RA, Diez-Fuertes F, Alcami J, Aloy P, Garcia F. Vaccines.
Tissue-specific differences in HIV DNA levels and mechanisms that govern HIV transcription in blood, gut, genital tract and liver in ART-treated women. Moron-Lopez S, Xie G, Kim P, Siegel DA, Lee S, Wong JK, Price JC, Elnachef N, Greenblatt RM, Tien PC, Roan NR, Yukl SA. J Int AIDS Soc. 2021 Jul;24(7):e25738.
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June 2021
Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV.
Giron LB, Palmer CS, Liu Q, Yin X, Papasavvas E, Sharaf R, Etemad B, Damra M, Goldman AR, Tang HY, Johnston R, Mounzer K, Kostman JR, Tebas P, Landay A, Montaner LJ, Jacobson JM, Li JZ, Abdel-Mohsen M. Nat Commun. 2021 Jun 29;12(1):3922.
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Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients.
Giron LB, Dweep H, Yin X, Wang H, Damra M, Goldman AR, Gorman N, Palmer CS, Tang HY, Shaikh MW, Forsyth CB, Balk RA, Zilberstein NF, Liu Q, Kossenkov A, Keshavarzian A, Landay A, Abdel-Mohsen M. Front Immunol. 2021 Jun 9;12:686240.
Persistence of HIV After Allogeneic Bone Marrow Transplant in a Dually Infected Individual.
Capoferri AA, Redd AD, Gocke CD, Clark LR, Ambinder RF, Durand CM. AIDS Res Hum Retroviruses. 2021 Jul 5. doi: 10.1089/AID.2021.0047.
Antibodies from rabbits immunized with HIV-1 clade B SOSIP trimers can neutralize multiple clade B viruses by destabilizing the envelope glycoprotein.
van Haaren MM, McCoy LE, Torres JL, Lee W, Cottrell CA, Copps JL, van der Woude P, Yasmeen A, de Taeye SW, de la Peña AT, Moore JP, Burton DR, Klasse PJ, Ward AB, Sanders RW, van Gils MJ. J Virol. 2021 Jun 2:JVI0009421. doi: 10.1128/JVI.00094-21.
May 2021
Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF. Cell. 2021 May 27;184(11):2955-2972.
Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset.
Anand SP, Prévost J, Nayrac M, Beaudoin-Bussières G, Benlarbi M, Gasser R, Brassard N, Laumaea A, Gong SY, Bourassa C, Brunet-Ratnasingham E, Medjahed H, Gendron-Lepage G, Goyette G, Gokool L, Morrisseau C, Bégin P, Martel-Laferrière V, Tremblay C, Richard J, Bazin R, Duerr R, Kaufmann DE, Finzi A. Cell Reports Medicine doi: 10.1101/2021.01.25.428097.
Cellular activation, differentiation and proliferation influence the dynamics of genetically-intact proviruses over time.
Horsburgh BA, Hiener B, Fisher K, Lee E, Morgan H, Eden JS, von Stockenstrom S, Odevall L, Milush JM, Hoh R, Fromentin R, Chomont N, Hecht FM, Schlub TE, Deeks SG, Palmer S. J Infect Dis. 2021 May 26:jiab291. doi: 10.1093/infdis/jiab291.
Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir.
Rajashekar JK, Richard J, Beloor J, Prévost J, Anand SP, Beaudoin-Bussières G, Shan L, Herndler-Brandstetter D, Gendron-Lepage G, Medjahed H, Bourassa C, Gaudette F, Ullah I, Symmes K, Peric A, Lindemuth E, Bibollet-Ruche F, Park J, Chen HC, Kaufmann DE, Hahn BH, Sodroski J, Pazgier M, Flavell RA, Smith AB 3rd, Finzi A, Kumar P. Cell Host Microbe. 2021 May 18:S1931-3128(21)00190-6.
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April 2021
Ethical and practical considerations for mitigating risks to sexual partners during analytical treatment interruptions in HIV cure-related research.
Dubé K, Kanazawa J, Dee L, Taylor J, Campbell DM, Brown B, Johnson MO, Saberi P, Sauceda JA, Sugarman J, Peluso MJ. HIV Res Clin Pract. 2021 Feb;22(1):14-30.
Optimization of AAV vectors to target persistent viral reservoirs.
Colón-Thillet R, Jerome KR, Stone D. Virol J. 2021 Apr 23;18(1):85.
Robust CAR-T memory formation and function via hematopoietic stem cell delivery.
Zhen A, Carrillo MA, Mu W, Rezek V, Martin H, Hamid P, Chen ISY, Yang OO, Zack JA, Kitchen SG. PLoS Pathog. 2021 Apr 1;17(4):e1009404.
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Characterization of HIV-induced remodeling reveals differences in infection susceptibility of memory CD4(+) T cell subsets in vivo.
Xie G, Luo X, Ma T, Frouard J, Neidleman J, Hoh R, Deeks SG, Greene WC, Roan NR. Cell Rep. 2021 Apr 27;35(4):109038.
Characterization of HIV-induced remodeling reveals differences in infection susceptibility of memory CD4(+) T cell subsets in vivo.
Xie G, Luo X, Ma T, Frouard J, Neidleman J, Hoh R, Deeks SG, Greene WC, Roan NR. Cell Rep. 2021 Apr 27;35(4):109038.
Shock-and-kill versus block-and-lock: Targeting the fluctuating and heterogeneous HIV-1 gene expression.
Yeh YJ, Ho YC. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):e2103692118
March 2021
Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo.
Gramatica A, Schwarzer R, Brantley W, Varco-Merth B, Sperber HS, Hull PA, Montano M, Migueles SA, Rosenthal D, Hogan LE, Johnson JR, Packard TA, Grimmett ZW, Herzig E, Besnard E, Nekorchuk M, Hsiao F, Deeks SG, Snape M, Kiernan B, Roan NR, Lifson JD, Estes JD, Picker LJ, Verdin E, Krogan NJ, Henrich TJ, Connors M, Ott M, Pillai SK, Okoye AA, Greene WC. Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo. J Virol. 2021 Mar 25;95(8):e02393-20. doi: 10.1128/JVI.02393-20.
A functional screen identifies transcriptional networks that regulate HIV-1 and HIV-2.
Pedro KD, Agosto LM, Sewell JA, Eberenz KA, He X, Fuxman Bass JI, Henderson AJ. Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):e2012835118. doi: 10.1073/pnas.2012835118.
Impact of anti-PD-1 and anti-CTLA-4 on the HIV reservoir in people living with HIV with cancer on antiretroviral therapy: The AIDS Malignancy Consortium-095 study.
Rasmussen TA, Rajdev L, Rhodes A, Dantanarayana A, Tennakoon S, Chea S, Spelman T, Lensing S, Rutishauser R, Bakkour S, Busch M, Siliciano JD, Siliciano RF, Einstein MH, Dittmer DP, Chiao E, Deeks S, Durand C, Lewin SR. Clin Infect Dis. 2021 Mar 2:ciaa1530. doi: 10.1093/cid/ciaa1530.
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February 2021
Participant Perspectives and Experiences Entering an Intensively Monitored Antiretroviral Pause (IMAP): Results from the AIDS Clinical Trials Group (ACTG) A5345 Biomarker Study.
Diepstra KL, Barr L, Palm D, Hogg E, Mollan K, Henley L, Stover A, Simoni J, Sugarman J, Brown B, Sauceda JA, Deeks SG, Fox L, Gandhi R, Smith DM, Li J, Dube K. AIDS Res Hum Retroviruses. 2021 Jan 20. doi: 10.1089/AID.2020.0222.
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A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.
Zhou S, Butler-Laporte G, Nakanishi T, Morrison DR, Afilalo J, Afilalo M, Laurent L, Pietzner M, Kerrison N, Zhao K, Brunet-Ratnasingham E, Henry D, Kimchi N, Afrasiabi Z, Rezk N, Bouab M, Petitjean L, Guzman C, Xue X, Tselios C, Vulesevic B, Adeleye O, Abdullah T, Almamlouk N, Chen Y, Chassé M, Durand M, Paterson C, Normark J, Frithiof R, Lipcsey M, Hultström M, Greenwood CMT, Zeberg H, Langenberg C, Thysell E, Pollak M, Mooser V, Forgetta V, Kaufmann DE, Richards JB. Nat Med. 2021 Apr;27(4):659-667.
Single-Molecule FRET Imaging of Virus Spike-Host Interactions.
Lu M. Viruses. 2021 Feb 21;13(2):332.
January 2021
“I would really want to know that they had my back”: Transgender women’s perceptions of HIV cure-related research in the United States.
Poteat T, Aqil A, Corbett D, Evans D, Dubé K. PLoS One. 2020 Dec 31;15(12):e0244490.
The single-cell landscape of immunological responses of CD4+ T cells in HIV versus severe acute respiratory syndrome coronavirus 2.
Collora JA, Liu R, Albrecht K, Ho YC. Curr Opin HIV AIDS. 2021 Jan;16(1):36-47.
Stem cell-derived CAR T cells traffic to HIV reservoirs in macaques.
Barber-Axthelm IM, Barber-Axthelm V, Sze KY, Zhen A, Suryawanshi GW, Chen IS, Zack JA, Kitchen SG, Kiem HP, Peterson CW. JCI Insight. 2021 Jan 11;6(1):e141502. doi: 10.1172/jci.insight.141502.
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No detectable alloreactive transcriptional responses under standard sample preparation conditions during donor-multiplexed single-cell RNA sequencing of peripheral blood mononuclear cells.
McGinnis CS, Siegel DA, Xie G, Hartoularos G, Stone M, Ye CJ, Gartner ZJ, Roan NR, Lee SA. BMC Biol. 2021 Jan 20;19(1):10.
Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART.
Bacchus-Souffan C, Fitch M, Symons J, Abdel-Mohsen M, Reeves DB, Hoh R, Stone M, Hiatt J, Kim P, Chopra A, Ahn H, York VA, Cameron DL, Hecht FM, Martin JN, Yukl SA, Mallal S, Cameron PU, Deeks SG, Schiffer JT, Lewin SR, Hellerstein MK, McCune JM, Hunt PW. PLoS Pathog. 2021 Jan 19;17(1):e1009214.
December 2020
Adeno-associated virus (AAV) capsid engineering in liver-directed gene therapy.
Rodríguez-Márquez E, Meumann N, Büning H. Expert Opin Biol Ther. 2020 Dec 30:1-18. doi: 10.1080/14712598.2021.1865303.
TCF-1 regulates HIV-specific CD8+ T cell expansion capacity
Rachel L Rutishauser, Christian Deo T Deguit, Joseph Hiatt, Franziska Blaeschke, Theodore L Roth, Lynn Wang, Kyle A Raymond, Carly E Starke, Joseph C Mudd, Wenxuan Chen, Carolyn P Smullin, Rodrigo Matus-Nicodemos, Rebecca Hoh, Melissa R Krone, Frederick M Hecht, Christopher D Pilcher, Jeffrey N Martin, Richard A Koup, Daniel C Douek, Jason M Brenchley, Rafick-Pierre Sékaly, Satish K Pillai, Alexander Marson, Steven G Deeks, Joseph M McCune, Peter W Hunt
2020 Dec 22;136648. doi: 10.1172/jci.insight.136648.
Rapid Evolution of HERC6 and Duplication of a Chimeric HERC5/6 Gene in Rodents and Bats Suggest an Overlooked Role of HERCs in Mammalian Immunity.
Jacquet S, Pontier D, Etienne L. Front Immunol. 2020 Dec 18;11:605270. doi: 10.3389/fimmu.2020.605270. eCollection 2020.
Decline of Humoral Responses against SARS-CoV-2 Spike in Convalescent Individuals.
Beaudoin-Bussières G, Laumaea A, Anand SP, Prévost J, Gasser R, Goyette G, Medjahed H, Perreault J, Tremblay T, Lewin A, Gokool L, Morrisseau C, Bégin P, Tremblay C, Martel-Laferrière V, Kaufmann DE, Richard J, Bazin R, Finzi A. mBio. 2020 Oct 16;11(5):e02590-20.
Human splice factors contribute to latent HIV infection in primary cell models and blood CD4+ T cells from ART-treated individuals.
Moron-Lopez S, Telwatte S, Sarabia I, Battivelli E, Montano M, Macedo AB, Aran D, Butte AJ, Jones RB, Bosque A, Verdin E, Greene WC, Wong JK, Yukl SA. PLoS Pathog. 2020 Nov 30;16(11):e1009060. doi: 10.1371/journal.ppat.1009060. eCollection 2020 Nov.
November 2020
Comprehensive mapping of the human cytokine gene regulatory network.
Santoso CS, Li Z, Lal S, Yuan S, Gan KA, Agosto LM, Liu X, Pro SC, Sewell JA, Henderson A, Atianand MK, Fuxman Bass JI. Nucleic Acids Res. 2020 Nov 12:gkaa1055. doi: 10.1093/nar/gkaa1055.
Acceptability, motivation and the prospect of cure for people living with HIV and their healthcare providers in HIV cure-focused treatment interruption studies.
Lau JSY, Smith MZ, Allan B, Martinez C, Power J, Lewin SR, McMahon JH. AIDS Res Ther. 2020 Nov 10;17(1):65.
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A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide.
Ozorowski G, Torres JL, Santos-Martins D, Forli S, Ward AB. Cell Rep. 2020 Nov 24;33(8):108428
Diverse HIV-1 escape pathways from broadly neutralizing antibody PGDM1400 in humanized mice.
van der Velden YU, Villaudy J, Siteur-van Rijnstra E, van der Linden CA, Vink MA, Schermer EE, Weijer K, Berkhout B, Sanders RW, van Gils MJ. MAbs. 2020 Jan-Dec;12(1):1845908.
October 2020
Macrophage maturation from blood monocytes is altered in people with HIV, and is linked to serum lipid profiles and activation indices: A model for studying atherogenic mechanisms.
Bowman ER, Cameron CM, Richardson B, Kulkarni M, Gabriel J, Cichon MJ, Riedl KM, Mustafa Y, Cartwright M, Snyder B, Raman SV, Zidar DA, Koletar SL, Playford MP, Mehta NN, Sieg SF, Freeman ML, Lederman MM, Cameron MJ, Funderburg NT. PLoS Pathog. 2020 Oct 1;16(10):e1008869
Mining for humoral correlates of HIV control and latent reservoir size.
Das J, Devadhasan A, Linde C, Broge T, Sassic J, Mangano M, O’Keefe S, Suscovich T, Streeck H, Irrinki A, Pohlmeyer C, Min-Oo G, Lin S, Weiner JA, Cihlar T, Ackerman ME, Julg B, Deeks S, Lauffenburger DA, Alter G. PLoS Pathog. 2020 Oct 13;16(10):e1008868.
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Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells.
Yukl SA, Khan S, Chen TH, Trapecar M, Wu F, Xie G, Telwatte S, Fulop D, Pico AR, Laird GM, Ritter KD, Jones NG, Lu CM, Siliciano RF, Roan NR, Milush JM, Somsouk M, Deeks SG, Hunt PW, Sanjabi S. J Virol. 2020 Oct 28:JVI.01331-20. doi: 10.1128/JVI.01331-20.
Association of Viral Persistence and Atherosclerosis in Adults With Treated HIV Infection.
McLaughlin MM, Ma Y, Scherzer R, Rahalkar S, Martin JN, Mills C, Milush J, Deeks SG, Hsue PY. JAMA Netw Open. 2020 Oct 1;3(10):e2018099. doi: 10.1001/jamanetworkopen.2020.18099.
Targeted Chromatinization and Repression of HIV-1 Provirus Transcription with Repurposed CRISPR/Cas9.
Olson A, Basukala B, Lee S, Gagne M, Wong WW, Henderson AJ. Viruses. 2020 Oct 12;12(10):1154. doi: 10.3390/v12101154.
Leveraging the advances in HIV for COVID-19.
McMahon JH, Hoy JF, Kamarulzaman A, Bekker LG, Beyrer C, Lewin SR. Lancet. 2020 Oct 3;396(10256):943-944. doi: 10.1016/S0140-6736(20)32012-2.
September 2020
Recommendations for measuring HIV reservoir size in cure-directed clinical trials.
Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR, Spivak AM, Planelles V, Hahn BH, Smith DM, Ho YC, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I, Riley JL, Tebas P, Montaner LJ; BEAT-HIV Delaney Collaboratory to Cure HIV-1 infection. Nat Med. 2020 Sep;26(9):1339-1350.
A targeted reactivation of latent HIV-1 using an activator vector in patient samples from acute infection.
Mann JFS, Pankrac J, Klein K, McKay PF, King DFL, Gibson R, Wijewardhana CN, Pawa R, Meyerowitz J, Gao Y, Canaday DH, Avino M, Poon AFY, Foster C, Fidler S, Shattock RJ, Arts EJ.
EBioMedicine. 2020 Sep;59:102853. doi: 10.1016/j.ebiom.2020.102853.
Allogeneic bone marrow transplantation with post-transplant cyclophosphamide for patients with HIV and haematological malignancies: a feasibility study.
Durand CM, Capoferri AA, Redd AD, Zahurak M, Rosenbloom DIS, Cash A, Avery RK, Bolaños-Meade J, Bollard CM, Bullen CK, Flexner C, Fuchs EJ, Gallant J, Gladstone DE, Gocke CD, Jones RJ, Kasamon YL, Lai J, Levis M, Luznik L, Marr KA, McHugh HL, Mehta Steinke S, Pham P, Pohlmeyer C, Pratz K, Shoham S, Wagner-Johnston N, Xu D, Siliciano JD, Quinn TC, Siliciano RF, Ambinder RF.
Lancet HIV. 2020 Sep;7(9):e602-e610.
Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir.
Neidleman J, Luo X, Frouard J, Xie G, Hsiao F, Ma T, Morcilla V, Lee A, Telwatte S, Thomas R, Tamaki W, Wheeler B, Hoh R, Somsouk M, Vohra P, Milush J, James KS, Archin NM, Hunt PW, Deeks SG, Yukl SA, Palmer S, Greene WC, Roan NR. Elife. 2020 Sep 29;9:e60933. doi: 10.7554/eLife.60933.
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Mechanistic differences underlying HIV latency in the gut and blood contribute to differential responses to latency-reversing agents.
Telwatte S, Kim P, Chen TH, Milush JM, Somsouk M, Deeks SG, Hunt PW, Wong JK, Yukl SA. AIDS. 2020 Sep 8. doi: 10.1097/QAD.0000000000002684.
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DGINN, an automated and highly-flexible pipeline for the detection of genetic innovations on protein-coding genes.
Picard L, Ganivet Q, Allatif O, Cimarelli A, Guéguen L, Etienne L. Nucleic Acids Res. 2020 Sep 17:gkaa680. doi: 10.1093/nar/gkaa680.
Gene transfer in AAV seropositive rhesus macaques following rapamycin treatment and subcutaneous delivery of AAV6 but not retargeted AAV6 vectors.
Stone D, Kenkel EJ, Loprieno MA, Tanaka M, De Silva Feelixge HS, Kumar AK, Stensland L, Obenza WM, Wangari S, Ahrens CY, Murnane RD, Peterson C, Kiem HP, Huang ML, Aubert M, Hu SL, Jerome KR. Hum Gene Ther. 2020 Sep 30. doi: 10.1089/hum.2020.113.
Resistance Profile of Human Immunodeficiency Virus 1 (HIV-1) Quasispecies in Patients Under Treatment Failure Using Single Molecule, Real-Time (SMRT) Sequencing.
Monaco DC, Zapata L, Hunter E, Salomon H, Dilernia DA. AIDS. 2020 Sep 25. doi: 10.1097/QAD.0000000000002697.
Neutralizing antibody responses induced by HIV-1 envelope glycoprotein SOSIP trimers derived from elite neutralizers.
Schorcht A, van den Kerkhof TLGM, Cottrell CA, Allen JD, Torres JL, Behrens AJ, Schermer EE, Burger JA, de Taeye SW, de la Peña AT, Bontjer I, Gumbs S, Ozorowski G, LaBranche CC, de Val N, Yasmeen A, Klasse PJ, Montefiori DC, Moore JP, Schuitemaker H, Crispin M, van Gils MJ, Ward AB, Sanders RW. J Virol. 2020 Sep 30:JVI.01214-20. doi: 10.1128/JVI.01214-20.
August 2020
Interferon-α alters host glycosylation machinery during treated HIV infection.
Giron LB, Colomb F, Papasavvas E, Azzoni L, Yin X, Fair M, Anzurez A, Damra M, Mounzer K, Kostman JR, Tebas P, O’Doherty U, Tateno H, Liu Q, Betts MR, Montaner LJ, Abdel-Mohsen M. EBioMedicine. 2020 Aug 19;59:102945. doi: 10.1016/j.ebiom.2020.102945.
Sialyl-LewisX Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy.
Colomb F, Giron LB, Kuri-Cervantes L, Adeniji OS, Ma T, Dweep H, Battivelli E, Verdin E, Palmer CS, Tateno H, Kossenkov AV, Roan NR, Betts MR, Abdel-Mohsen M. Cell Rep. 2020 Aug 4;32(5):107991. doi: 10.1016/j.celrep.2020.107991.
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Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART.
Gantner P, Pagliuzza A, Pardons M, Ramgopal M, Routy JP, Fromentin R, Chomont N. Nat Commun. 2020 Aug 14;11(1):4089.
Immunometabolism and HIV-1 pathogenesis: food for thought.
Sáez-Cirión A, Sereti I. Nat Rev Immunol. 2020 Aug 6. doi: 10.1038/s41577-020-0381-7.
Operationalizing HIV cure-related trials with analytic treatment interruptions during the SARS-CoV-2 pandemic: A collaborative approach.
Peluso MJ, Dee L, Shao S, Taylor J, Campbell D, Collins S, Gandhi M, Johnston R, Deeks SG, Sauceda JA, Dubé K. Clin Infect Dis. 2020 Aug 25:ciaa1260. doi: 10.1093/cid/ciaa1260.
Everolimus, an mTORC1/2 inhibitor, in ART-suppressed individuals who received solid organ transplantation: A prospective study.
Henrich TJ, Schreiner C, Cameron C, Hogan LE, Richardson B, Rutishauser RL, Deitchman AN, Chu S, Rogers R, Thanh C, Gibson EA, Zarinsefat A, Bakkour S, Aweeka F, Busch MP, Liegler T, Baker C, Milush J, Deeks SG, Stock PG. Am J Transplant. 2020 Aug 11. doi: 10.1111/ajt.16244.
Distinct viral reservoirs in individuals with spontaneous control of HIV-1.
Jiang C, Lian X, Gao C, Sun X, Einkauf KB, Chevalier JM, Chen SMY, Hua S, Rhee B, Chang K, Blackmer JE, Osborn M, Peluso MJ, Hoh R, Somsouk M, Milush J, Bertagnolli LN, Sweet SE, Varriale JA, Burbelo PD, Chun TW, Laird GM, Serrao E, Engelman AN, Carrington M, Siliciano RF, Siliciano JM, Deeks SG, Walker BD, Lichterfeld M, Yu XG. Nature. 2020 Aug 26. doi: 10.1038/s41586-020-2651-8.
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Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.
Cottrell CA, van Schooten J, Bowman CA, Yuan M, Oyen D, Shin M, Morpurgo R, van der Woude P, van Breemen M, Torres JL, Patel R, Gross J, Sewall LM, Copps J, Ozorowski G, Nogal B, Sok D, Rakasz EG, Labranche C, Vigdorovich V, Christley S, Carnathan DG, Sather DN, Montefiori D, Silvestri G, Burton DR, Moore JP, Wilson IA, Sanders RW, Ward AB, van Gils MJ. PLoS Pathog. 2020 Aug 31;16(8):e1008753.
Large-scale site-specific mapping of the O-GalNAc glycoproteome.
Yang W, Song A, Ao M, Xu Y, Zhang H. Nat Protoc. 2020 Aug;15(8):2589-2610. doi: 10.1038/s41596-020-0345-1.
July 2020
Hepatitis C virus modulates IgG glycosylation in HIV co-infected antiretroviral therapy suppressed individuals.
Giron LB, Azzoni L, Yin X, Lynn KM, Ross BN, Fair M, Damra M, Sciorillo AC, Liu Q, Jacobson JM, Mounzer K, Kostman JR, Abdel-Mohsen M, Montaner LJ, Papasavvas E. AIDS. 2020 Aug 1;34(10):1461-1466. 32675559
Delayed Expression of PD-1 and TIGIT on HIV-Specific CD8 T Cells in Untreated HLA-B*57:01 Individuals Followed from Early Infection.
Scharf L, Tauriainen J, Buggert M, Hartogensis W, Nolan DJ, Deeks SG, Salemi M, Hecht FM, Karlsson AC. J Virol. 2020 Jul 1;94(14):e02128-19.
Long-Term TDF-Inclusive ART and Progressive Rates of HBsAg Loss in HIV-HBV Coinfection-Lessons for Functional HBV Cure?
Audsley J, Avihingsanon A, Littlejohn M, Bowden S, Matthews GV, Fairley CK, Lewin SR, Sasadeusz J. J Acquir Immune Defic Syndr. 2020 Aug 15;84(5):527-533.
Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2.
Hopfensperger K, Richard J, Stürzel CM, Bibollet-Ruche F, Apps R, Leoz M, Plantier JC, Hahn BH, Finzi A, Kirchhoff F, Sauter D. mBio. 2020 Jul 14;11(4):e00782-20.
SERINC5 Potently Restricts Retrovirus Infection In Vivo.
Timilsina U, Umthong S, Lynch B, Stablewski A, Stavrou S. mBio. 2020 Jul 14;11(4):e00588-20.
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Deficient uracil base excision repair leads to persistent dUMP in HIV proviruses during infection of monocytes and macrophages.
Meshesha M, Esadze A, Cui J, Churgulia N, Sahu SK, Stivers JT. PLoS One. 2020 Jul 14;15(7):e0235012.
June 2020
Intact HIV reservoir estimated by the intact proviral DNA assay correlates with levels of total and integrated DNA in the blood during suppressive antiretroviral therapy.
Papasavvas E, Azzoni L, Ross BN, Fair M, Yuan Z, Gyampoh K, Mackiewicz A, Sciorillo AC, Paggliuzza A, Lada SM, Wu G, Goh SL, Bahnck-Teets C, Holder DJ, Zuck PD, Damra M, Lynn KM, Tebas P, Mounzer K, Kostman JR, Abdel-Mohsen M, Richman D, Chomont N, Howell BJ, Montaner LJ. Clin Infect Dis. 2020 Jun 18:ciaa809. doi: 10.1093/cid/ciaa809.
FOXO1 Promotes HIV Latency by Suppressing ER Stress in T Cells.
Vallejo-Gracia A, Chen IP, Perrone R, Besnard E, Boehm D, Battivelli E, Tezil T, Krey K, Raymond KA, Hull PA , Walter M, Habrylo I, Cruz A, Deeks S , Pillai S, Verdin E, Ott M.
Nat Microbiol 2020; doi: 10.1038/s41564-020-0742-9.
Slow Receptor Binding of the Noncytopathic HIV-2UC1 Envs Is Balanced by Long-Lived Activation State and Efficient Fusion Activity.
Harris M, Ratnapriya S, Chov A, Cervera H, Block A, Gu C, Talledge N, Mansky LM, Sodroski J, Herschhorn A. Cell Rep. 2020 Jun 9;31(10):107749.
Altered immune reconstitution in HIV positive allogeneic stem cell transplant recipients.
Murray DD, Zaunders J, Milliken ST, Munier CML, Ford C, Morrissey CO, Visweswaran M, Avery S, Sasadeusz J, Kwan J, Desai S, Law M, Koelsch KK, Lewin SR, Moore J, Kelleher AD, Polizzotto MN.
Clin Infect Dis. 2020 Jun 10:ciaa748. doi: 10.1093/cid/ciaa748.
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HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite.
Nogal B, McCoy LE, van Gils MJ, Cottrell CA, Voss JE, Andrabi R, Pauthner M, Liang CH, Messmer T, Nedellec R, Shin M, Turner HL, Ozorowski G, Sanders RW, Burton DR, Ward AB. Sci Adv. 2020 Jun 5;6(23):eaba0512.
May 2020
‘Rinse and Replace’: Boosting T Cell Turnover To Reduce HIV-1 Reservoirs
Grossman Z, Singh NJ, Simonetti FR, Lederman MM, Douek DC, Deeks SG; Contributing authors.
Trends Immunol 2020 Jun;41(6):466-480.
Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1.
Eberhard JM, Angin M, Passaes C, Salgado M, Monceaux V, Knops E, Kobbe G, Jensen B, Christopeit M, Kröger N, Vandekerckhove L, Badiola J, Bandera A, Raj K, van Lunzen J, Hütter G, Kuball JHE, Martinez-Laperche C, Balsalobre P, Kwon M, Díez-Martín JL, Nijhuis M, Wensing A, Martinez-Picado J, Schulze Zur Wiesch J, Sáez-Cirión A.
Sci Transl Med. 2020 May 6;12(542):eaay9355.
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Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions.
Seabright GE, Cottrell CA, van Gils MJ, D’addabbo A, Harvey DJ, Behrens AJ, Allen JD, Watanabe Y, Scaringi N, Polveroni TM, Maker A, Vasiljevic S, de Val N, Sanders RW, Ward AB, Crispin M.
Structure. 2020 May 12:S0969-2126(20)30168-4.
A flexible nonlinear mixed effects model for HIV viral load rebound after treatment interruption.
Wang R, Bing A, Wang C, Hu Y, Bosch RJ, DeGruttola V.
Stat Med. 2020 Jul 10;39(15):2051-2066.
April 2020
Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection.
Hsiao F, Frouard J, Gramatica A, Xie G, Telwatte S, Lee GQ, Roychoudhury P, Schwarzer R, Luo X, Yukl SA, Lee S, Hoh R, Deeks SG, Jones RB, Cavrois M, Greene WC, Roan NR. PLoS Pathog.2020 Apr 30;16(4):e1008450.
Vaccines and Broadly Neutralizing Antibodies for HIV-1 Prevention.
Stephenson KE, Wagh K, Korber B, Barouch DH.
Annu Rev Immunol. 2020 Apr 26;38:673-703.
The immune response fails to control HIV early in initial virus spread.
Cohn LB, Deeks SG.
J Clin Invest. 2020 Apr 27. pii: 136886. doi: 10.1172/JCI136886.
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The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies.
Cohn LB, Chomont N, Deeks SG.
Cell Host Microbe. 2020 Apr 8;27(4):519-530.
Persistent expansion and Th1-like skewing of HIV-specific circulating T follicular helper cells during antiretroviral therapy.
Niessl J, Baxter AE, Morou A, Brunet-Ratnasingham E, Sannier G, Gendron-Lepage G, Richard J, Delgado GG, Brassard N, Turcotte I, Fromentin R, Bernard NF, Chomont N, Routy JP, Dubé M, Finzi A, Kaufmann DE.
EBioMedicine. 2020 Apr 5;54:102727.
March 2020
Sialylation and fucosylation modulate inflammasome-activating eIF2 Signaling and microbial translocation during HIV infection.
Giron LB, Tanes CE, Schleimann MH, Engen PA, Mattei LM, Anzurez A, Damra M, Zhang H, Bittinger K, Bushman F, Kossenkov A, Denton PW, Tateno H, Keshavarzian A, Landay AL, Abdel-Mohsen M.
Mucosal Immunol. 2020 Mar 9. doi: 10.1038/s41385-020-0279-5.
Assessing suitability of next-generation viral outgrowth assays as proxies for classic QVOA to measure HIV-1 latent reservoir size.
Stone M, Rosenbloom D, Bacchetti P, Deng X, Dimapasoc M, Keating S, Bakkour S, Richman D, Mellors J, Deeks S, Lai J, Beg S, Siliciano J, Pagliuzza A, Chomont N, Lackman-Smith C, Ptak RG, Busch MP; Reservoir Assay Validation and Evaluation Network (RAVEN) Study Group.
J Infect Dis. 2020 Mar 9. pii: jiaa089. doi: 10.1093/infdis/jiaa089. [Epub ahead of print]
Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection.
Leyre L, Kroon E, Vandergeeten C, Sacdalan C, Colby DJ, Buranapraditkun S, Schuetz A, Chomchey N, de Souza M, Bakeman W, Fromentin R, Pinyakorn S, Akapirat S, Trichavaroj R, Chottanapund S, Manasnayakorn S, Rerknimitr R, Wattanaboonyoungcharoen P, Kim JH, Tovanabutra S, Schacker TW, O’Connell R, Valcour VG, Phanuphak P, Robb ML, Michael N, Trautmann L, Phanuphak N, Ananworanich J, Chomont N; RV254/SEARCH010, RV304/SEARCH013, SEARCH011 study groups.
Sci Transl Med. 2020 Mar 4;12(533). pii: eaav3491. doi: 10.1126/scitranslmed.aav3491.
Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay.
Lee SA, Telwatte S, Hatano H, Kashuba ADM, Cottrell ML, Hoh R, Liegler TJ, Stephenson S, Somsouk M, Hunt PW, Deeks SG, Yukl S, Savic RM.
J Acquir Immune Defic Syndr. 2020 Apr 15;83(5):530-537. doi: 10.1097/QAI.0000000000002287.
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Participant Perspectives in an HIV Cure-Related Trial Conducted Exclusively in Women in the United States: Results from AIDS Clinical Trials Group (ACTG) 5366.
Dube K, Hosey L, Starr K, Barr L, Evans D, Hoffman E, Campbell D, Simoni J, Sugarman J, Sauceda J, Brown B, Diepstra KL, Godfrey C, Kuritzkes DR, Wohl DA, Gandhi R, Scully E.
AIDS Res Hum Retroviruses. 2020 Mar 11. doi: 10.1089/AID.2019.0284.
Evidence for HIV-1 cure after CCR5Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report.
Gupta RK, Peppa D, Hill AL, Gálvez C, Salgado M, Pace M, McCoy LE, Griffith SA, Thornhill J, Alrubayyi A, Huyveneers LEP, Nastouli E, Grant P, Edwards SG, Innes AJ, Frater J, Nijhuis M, Wensing AMJ, Martinez-Picado J, Olavarria E.
Lancet HIV. 2020 Mar 9. pii: S2352-3018(20)30069-2. doi: 10.1016/S2352-3018(20)30069-2.
A cure for HIV: how would we know?
Zerbato JM, Lewin SR.
Lancet HIV. 2020 Mar 9. pii: S2352-3018(20)30075-8. doi: 10.1016/S2352-3018(20)30075-8.
Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core.
Selyutina A, Persaud M, Simons LM, Bulnes-Ramos A, Buffone C, Martinez-Lopez A, Scoca V, Di Nunzio F, Hiatt J, Marson A, Krogan NJ, Hultquist JF, Diaz-Griffero F.
Cell Rep. 2020 Mar 17;30(11):3766-3777.
February 2020
A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption.
Michael J Peluso, Lynda Dee , Danielle Campbell , Jeff Taylor , Rebecca Hoh, Rachel L Rutishauser, John Sauceda, Steven G Deeks , Karine Dubé
JVE. 2020. 6:34-37
Differential decay of intact and defective proviral DNA in HIV-1-infected individuals on suppressive antiretroviral therapy.
Peluso MJ, Bacchetti P, Ritter KD, Beg SA, Lai J, Martin JN, Hunt PW, Henrich TJ, Siliciano JD, Siliciano RF, Laird GM, Deeks SG.
JCI Insight. 2020 Feb 11. pii: 132997. doi: 10.1172/jci.insight.132997.
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Reduce and Control: A Combinatorial Strategy for Achieving Sustained HIV Remissions in the Absence of Antiretroviral Therapy.
Schwarzer R, Gramatica A, Greene WC.
Viruses. 2020 Feb 8;12(2). pii: E188. doi: 10.3390/v12020188.
A systems approach to infectious disease.
Eckhardt M, Hultquist JF, Kaake RM, Hüttenhain R, Krogan NJ.
Nat Rev Genet. 2020 Feb 14. doi: 10.1038/s41576-020-0212-5.
Kick and kill for HIV latency.
Lewin SR, Rasmussen TA.
Lancet. 2020 Feb 18. pii: S0140-6736(20)30264-6. doi: 10.1016/S0140-6736(20)30264-6.
January 2020
Plasma and antibody glycomic biomarkers of time to HIV rebound and viral setpoint.
Giron LB, Papasavvas E, Azzoni L, Yin X, Anzurez A, Damra M, Mounzer K, Kostman JR, Sanne I, Firnhaber CS, Tateno H, Liu Q, Montaner LJ, Abdel-Mohsen M.
AIDS. 2020 Jan 17. doi: 10.1097/QAD.0000000000002476.
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High levels of genetically-intact HIV in HLA-DR+ memory T-cells indicates their value for reservoir studies.
Horsburgh BA, Lee E, Hiener B, Eden JS, Schlub TE, von Stockenstrom S, Odevall L, Milush JM, Liegler T, Sinclair E, Hoh R, Boritz EA, Douek DC, Fromentin R, Chomont N, Deeks SG, Hecht FM, Palmer S.
AIDS. 2020 Jan 6. doi: 10.1097/QAD.0000000000002465.
Combination Immune Checkpoint Blockade to Reverse HIV Latency.
Van der Sluis RM, Kumar NA, Pascoe RD, Zerbato JM, Evans VA, Dantanarayana AI, Anderson JL, Sékaly RP, Fromentin R, Chomont N, Cameron PU, Lewin SR.
J Immunol. 2020 Jan 27. pii: ji1901191. doi: 10.4049/jimmunol.1901191.
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HIV-1 Vpu downregulates Tim-3 from the surface of infected CD4+ T cells.
Prévost J, Edgar CR, Richard J, Trothen SM, Jacob RA, Mumby MJ, Pickering S, Dubé M, Kaufmann DE, Kirchhoff F, Neil SJD, Finzi A, Dikeakos JD.
J Virol. 2020 Jan 15. pii: JVI.01999-19. doi: 10.1128/JVI.01999-19.
Autologous neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened in rabbits.
Yang YR, McCoy LE, van Gils MJ, Andrabi R, Turner HL, Yuan M, Cottrell CA, Ozorowski G, Voss J, Pauthner M, Polveroni TM, Messmer T, Wilson IA, Sanders RW, Burton DR, Ward AB.
J Virol. 2020 Jan 15. pii: JVI.01861-19. doi: 10.1128/JVI.01861-19.